CaM Kinase IV substrate: sc-3028

CaM Kinase IV substrate, a peptide sequence targeted by Ca2+/calmodulin-dependent protein kinase IV (CaMKIV), serves as a crucial mediator in intracellular signaling cascades implicated in neuronal plasticity, learning, and memory formation. Upon activation by calcium-bound calmodulin, CaMKIV phosphorylates specific residues within the substrate, thereby regulating downstream effectors involved in synaptic transmission and neuronal development. Research involving CaM Kinase IV substrate has provided invaluable insights into the molecular mechanisms governing synaptic plasticity and cognitive processes. Studies utilizing this substrate have explaind the role of CaMKIV signaling in neuronal survival, dendritic spine morphogenesis, and long-term potentiation (LTP), a cellular mechanism underlying learning and memory. Furthermore, investigations employing CaM Kinase IV substrate have contributed to our understanding of neurological disorders characterized by aberrant synaptic plasticity, such as Alzheimer′s disease and autism spectrum disorders. Through its application in deciphering signaling pathways associated with synaptic function and cognitive function, CaM Kinase IV substrate remains a fundamental tool in neuroscience research, paving the way for the development of novel strategies targeting synaptic dysfunction and cognitive impairment.