Date published: 2025-10-16

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C16 Dihydroceramide (CAS 5966-29-0)

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Application:
C16 Dihydroceramide is a dihydroceramide compound
CAS Number:
5966-29-0
Molecular Weight:
539.92
Molecular Formula:
C34H69NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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C16 Dihydroceramide, cataloged under CAS number 5966-29-0, is a synthetic sphingolipid analog characterized by a saturated 16-carbon fatty acid attached to a sphingosine backbone. This compound mimics the structure of naturally occurring ceramides but lacks the double bond typically found in the sphingosine portion of natural ceramides, which imparts distinct biophysical properties to the molecule. In cellular and molecular research, C16 Dihydroceramide is extensively used to investigate the roles of ceramides in cellular signaling pathways, particularly those related to stress response, cell cycle regulation, and apoptosis. The absence of the double bond in dihydroceramides like C16 Dihydroceramide makes them more resistant to oxidation, thereby providing a stable model to study the effects of ceramides in oxidative environments. Researchers utilize this compound to dissect the specific contributions of ceramides to membrane structure, fluidity, and function, as well as their interactions with other bioactive molecules within the cell. By exploring the dynamics of C16 Dihydroceramide within various cellular contexts, scientists can better understand the complex network of lipid-mediated signaling that influences cell behavior, survival, and adaptation to both internal and external stimuli. This research explains fundamental aspects of cell biology and contributes to broader scientific knowledge on lipidomics and cell membrane dynamics.


C16 Dihydroceramide (CAS 5966-29-0) References

  1. Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling.  |  Hamai, H., et al. 2009. J Lipid Res. 50: 1101-8. PMID: 19144995
  2. Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.  |  Gustafsson, K., et al. 2009. Mol Cancer Res. 7: 1086-98. PMID: 19609004
  3. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.  |  Mullen, TD., et al. 2011. J Lipid Res. 52: 68-77. PMID: 20940143
  4. Enhanced killing of SCC17B human head and neck squamous cell carcinoma cells after photodynamic therapy plus fenretinide via the de novo sphingolipid biosynthesis pathway and apoptosis.  |  Boppana, NB., et al. 2015. Int J Oncol. 46: 2003-10. PMID: 25739041
  5. Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway.  |  Boppana, NB., et al. 2016. J Photochem Photobiol B. 159: 191-5. PMID: 27085050
  6. Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.  |  Boppana, NB., et al. 2017. Anticancer Res. 37: 455-463. PMID: 28179290
  7. Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.  |  Savira, F., et al. 2021. Toxicol Lett. 350: 133-142. PMID: 34303789
  8. Novel insight into the mechanism underlying synergistic cytotoxicity from two components in 5-Fluorouracil-phenylalanine co-crystal based on cell metabolomics.  |  Hao, H., et al. 2022. Eur J Pharm Biopharm. 180: 181-189. PMID: 36220522
  9. The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury.  |  Wedel, S., et al. 2022. Int J Mol Sci. 23: PMID: 36430751
  10. Quantitative analysis of ceramide molecular species by high performance liquid chromatography.  |  Yano, M., et al. 1998. J Lipid Res. 39: 2091-8. PMID: 9788256

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C16 Dihydroceramide, 5 mg

sc-210985
5 mg
$320.00