C-390 (CAS 77769-31-4)

C-390 is a benzothiopyranoindazole derivative known for its potent inhibitory effects on bacterial cell division. The primary mechanism of action of C-390 involves targeting and inhibiting the bacterial cell division protein FtsZ, which is essential for the formation of the Z-ring at the future site of cytokinesis. By binding to FtsZ, C-390 disrupts its polymerization and GTPase activity, thereby preventing the formation of the division septum and leading to cell elongation and eventual cell death. This unique mechanism makes C-390 a valuable tool in microbiological research. In scientific studies, C-390 is used extensively to explore the dynamics of bacterial cell division and to understand the structural and functional aspects of FtsZ. Researchers employ C-390 to investigate the molecular mechanisms underlying FtsZ polymerization and its role in the bacterial cytokinetic process. Additionally, C-390 serves as a model compound in the development of new antibacterial agents that target cell division, providing insights into the design of novel inhibitors with enhanced efficacy and specificity. The compound′s effectiveness against a wide range of bacterial species makes it an important agent in studies aimed at combating antibiotic resistance. By elucidating the interactions between C-390 and FtsZ, researchers gain a deeper understanding of bacterial cell biology and identify new targets for antibacterial drug development. Overall, C-390′s applications in research significantly contribute to advancing the field of microbiology and the development of innovative antimicrobial strategies.