Molecular structure of BW B70C, CAS Number: 134470-38-5
BW B70C (CAS 134470-38-5)
Alternate Names:
N-(3-(3-(4-Fluorophenoxy)phenyl)-1-methyl-2-propenyl)-N-hydroxyurea
Application:
BW B70C is a 5-LO (5-lipoxygenase) inhibitor
CAS Number:
134470-38-5
Molecular Weight:
316.3
Molecular Formula:
C17H17FN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
BW B70C is a selective arachidonic acid 5-LO (5-lipoxygenase) inhibitor. Guinea-pig lung studies report that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, decreases the migration for leukocyte to the airway lumen, and weakens glycoconjugate secretion and airway closure. BW B70C has been reported to hyper-activate monocytes, decrease the formation of oligonucleosomal and high molecular weight DNA fragments. Additional studies demonstrate that BW B70C decreases 12-HETE formation in MAC26 cells.
BW B70C (CAS 134470-38-5) References
- Lyprinol inhibits LTB4 production by human monocytes. | Dugas, B. 2000. Allerg Immunol (Paris). 32: 284-9. PMID: 11094642
- Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells. | Vanags, DM., et al. 1997. Cell Death Differ. 4: 479-86. PMID: 16465269
- Identification of key genes and pathways and therapeutic agents in cadmium-treated liver cells: A bioinformatics study. | Zhang, L., et al. 2017. Environ Toxicol Pharmacol. 56: 145-150. PMID: 28934692
- PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. | Villegas, SN., et al. 2018. Cell Rep. 22: 2541-2549. PMID: 29514083
- A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. | Xiong, DD., et al. 2018. J Transl Med. 16: 220. PMID: 30092792
- Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. | Lane, NJ., et al. 1994. Transplantation. 58: 1303-8. PMID: 7809921
- Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. | Yeadon, M., et al. 1993. Agents Actions. 38: 8-18. PMID: 8480540
- Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138. | Yeadon, M., et al. 1995. Pulm Pharmacol. 8: 53-63. PMID: 8535100
- Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation. | Dugas, N., et al. 1996. Immunology. 88: 384-8. PMID: 8774354
- Inhibition of tumour growth by lipoxygenase inhibitors. | Hussey, HJ. and Tisdale, MJ. 1996. Br J Cancer. 74: 683-7. PMID: 8795568
- 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. | Bureau, MF., et al. 1997. Eur J Pharmacol. 324: 89-98. PMID: 9137918
Inhibitor of:
5-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BW B70C, 5 mg | sc-200633 | 5 mg | $83.00 | |||
BW B70C, 10 mg | sc-200633B | 10 mg | $166.00 | |||
BW B70C, 25 mg | sc-200633A | 25 mg | $592.00 | |||
BW B70C, 50 mg | sc-200633C | 50 mg | $739.00 | |||
BW B70C, 100 mg | sc-200633D | 100 mg | $1200.00 | |||
BW B70C, 250 mg | sc-200633E | 250 mg | $2000.00 |