Buparvaquone (CAS 88426-33-9)

Buparvaquone, a hydroxynaphthoquinone derivative, is extensively studied in scientific research for its unique mechanism of action targeting mitochondrial function in protozoan parasites. This compound specifically inhibits the cytochrome bc1 complex (complex III) within the mitochondrial electron transport chain, disrupting the production of ATP and leading to the collapse of cellular energy metabolism in the parasites. Research on buparvaquone provides valuable insights into the biochemistry of mitochondrial electron transport and the bioenergetics of eukaryotic cells. Buparvaquone has been employed in various studies to understand the resistance mechanisms that protozoan parasites develop against quinone-based inhibitors. By examining how mutations in the cytochrome bc1 complex confer resistance, researchers can gain a deeper understanding of the molecular adaptations of parasites to drug pressure. Additionally, buparvaquone′s effects on cellular redox states and oxidative stress responses are investigated to explore how disruption of mitochondrial function impacts overall cell physiology and survival. In agricultural and veterinary research, buparvaquone is used to study its efficacy and mechanism of action against protozoan parasites affecting livestock, contributing to the broader understanding of parasite control strategies. Through these research applications, buparvaquone significantly advances our knowledge of mitochondrial biology and parasite bioenergetics, providing a valuable tool for exploring cellular respiration and metabolic regulation.