Molecular structure of Buformin Hydrochloride, CAS Number: 1190-53-0
Buformin Hydrochloride (CAS 1190-53-0)
See product citations (8)
Alternate Names:
Butylbiguanide Hydrochloride; N-Butyl Biguanide Hydrochloride; Panformin; Sindiatil; Buformine HCl; n1-n-butylbiguanide hydrochloride; Biforon; Diabrin
Application:
Buformin Hydrochloride is an antihyperglycemic agent that helps delay the absorptio nof glucose in the GI tract
CAS Number:
1190-53-0
Purity:
≥95%
Molecular Weight:
193.68
Molecular Formula:
C6H15N5•HCl
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Clinically used for diabetes mellitus, it is known to improve resistance to insulin in patients by suppressing the expression of glyceraldehyde 3-phosphate dehydrogenase.
Buformin Hydrochloride (CAS 1190-53-0) References
- Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. | Owen, MR., et al. 2000. Biochem J. 348 Pt 3: 607-14. PMID: 10839993
- Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function. | Detaille, D., et al. 2002. Biochem Pharmacol. 63: 1259-72. PMID: 11960602
- A validated HPLC method with ultraviolet detection for the determination of buformin in plasma. | Chou, CH., et al. 2004. Biomed Chromatogr. 18: 254-8. PMID: 15162388
- Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. | Yano, A., et al. 2006. Biol Pharm Bull. 29: 1006-9. PMID: 16651735
- The enhancement of oxidative DNA damage by anti-diabetic metformin, buformin, and phenformin, via nitrogen-centered radicals. | Ohnishi, S., et al. 2016. Free Radic Res. 50: 929-37. PMID: 27328723
- Sensitive determination of buformin using poly-aminobenzoic acid modified glassy carbon electrode. | Jin, GY., et al. 2012. J Pharm Anal. 2: 458-461. PMID: 29403783
- The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or WZB-117 Inhibit the Viability of Highly Resistant Human Lung Cancer Cells. | Yakisich, JS., et al. 2019. Stem Cells Int. 2019: 6254269. PMID: 30918522
- Low-dose metformin targets the lysosomal AMPK pathway through PEN2. | Ma, T., et al. 2022. Nature. 603: 159-165. PMID: 35197629
- Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1. | Meyer, MJ., et al. 2022. J Biol Chem. 298: 101974. PMID: 35469921
- Graphene and zeolite as adsorbents in bar-micro-solid phase extraction of pharmaceutical compounds of diverse polarities. | Jajuli, MN., et al. 2021. RSC Adv. 11: 16297-16306. PMID: 35479128
- Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters. | Meyer, MJ., et al. 2022. Int J Mol Sci. 23: PMID: 35563491
- High-throughput screening of 756 chemical contaminants in aquaculture products using liquid chromatography/quadrupole time-of-flight mass spectrometry. | Bai, M., et al. 2022. Food Chem X. 15: 100380. PMID: 36211738
- Insights into the action of the pharmaceutical metformin: Targeted inhibition of the gut microbial enzyme agmatinase. | Tassoulas, LJ. and Wackett, LP. 2024. iScience. 27: 108900. PMID: 38318350
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NDUFA4L2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Buformin Hydrochloride, 100 mg | sc-207383 | 100 mg | $267.00 | |||
Buformin Hydrochloride, 500 mg | sc-207383A | 500 mg | $300.00 |