Bu-1b Antibody (5-11G2): sc-52452
- Bu-1b Antibody (5-11G2) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against bursal cells from 2- to 5-week-old CHA (Bu1b) strain avians
- recommended for detection of Bu-1b of avian origin by IP, IF and FCM; non cross-reactive with cells from CHA and H.B15Ab strains
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bu-1b Antibody (5-11G2). This work is in progress.
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Bu-1b Antibody (5-11G2) is a mouse monoclonal IgG1 antibody that detects Bu-1b in avian species through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Bu-1b is a genetically polymorphic cell surface antigen that plays a crucial role in the regulation of cell death, particularly during the development of B lymphocytes. Bu-1b functions as a type I transmembrane glycoprotein, which is essential for maintaining the balance between cell survival and apoptosis in the immune system. Bu-1b expression on B cells and a subset of macrophages indicates involvement in immune responses, as Bu-1b helps to eliminate nonfunctional or self-reactive lymphocytes, thereby preventing autoimmune reactions. Bu-1b expression in embryonic spleen and bone marrow cells marks these tissues as precursors for B cell development. Bu-1b′s ability to induce a rapid form of cell death similar to apoptosis underscores its importance in ensuring that only functional lymphocytes mature and enter the immune repertoire. The two allelic forms of the Bu-1 gene, Bu-1a and Bu-1b, represent the recessive and dominant products, respectively, further highlighting the genetic diversity and functional implications of this antigen in avian immunology.
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Bu-1b Antibody (5-11G2) References:
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- Benzannulated N-heterocyclic germylenes and stannylenes with sterically demanding N,N'-substituents. | Krupski, S., et al. 2014. Dalton Trans. 43: 173-81. PMID: 24121532
- Monoclonal antibodies against chicken Bu-1a and Bu-1b alloantigens. | Veromaa, T., et al. 1988. Hybridoma. 7: 41-8. PMID: 2453446
- Bu-1 antigen expression as a marker for B cell precursors in chicken embryos. | Houssaint, E., et al. 1989. Eur J Immunol. 19: 239-43. PMID: 2649381
- Genetic interaction between non-MHC T- and B-cell alloantigens in response to Rous sarcomas in chickens. | Gilmour, DG., et al. 1986. Immunogenetics. 23: 1-6. PMID: 3002975
- Influence of genotypes at a non-MHC B lymphocyte alloantigen locus (Bu-1) on expression of Ia (B-L) antigen on chicken bursal lymphocytes. | Fredericksen, TL. and Gilmour, DG. 1985. J Immunol. 134: 754-6. PMID: 3871215
- Identification of chicken Bu-1 alloantigens using the monoclonal antibody AV20. | Rothwell, CJ., et al. 1996. Vet Immunol Immunopathol. 55: 225-34. PMID: 9014319
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bu-1b Antibody (5-11G2) | sc-52452 | 100 µg/ml | $322.00 | |||
Bu-1b Antibody (5-11G2) PE | sc-52452 PE | 100 tests in 2 ml | $349.00 |