BTBD14B Antibody (E-3): sc-376216
- BTBD14B Antibody (E-3) is a mouse monoclonal IgG1 κ BTBD14B antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 284-357 mapping within an internal region of BTBD14B of human origin
- BTBD14B Antibody (E-3) is recommended for detection of BTBD14B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-BTBD14B Antibody (E-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for BTBD14B Antibody (E-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with BTBD14B Antibody (E-3) (see ordering information below).
BTBD14B Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects BTBD14B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-BTBD14B antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BTBD14B, also known as NACC1, BEND8, or NAC1, is a 527 amino acid protein that plays a crucial role in transcriptional regulation due to its unique structure, which includes a BTB (broad-complex, Tramtrack, and Bric a brac) domain. This domain enables BTBD14B to form homooligomers and interact with histone deacetylases HDAC3 and HDAC4, thereby functioning as a transcriptional repressor. BTBD14B′s localization in both the nucleus and cytoplasm allows for influencing CRIF1 transcriptional activity and facilitating proteasome recruitment to dendritic spines, which is vital for synaptic plasticity and neuronal function. Additionally, BTBD14B′s overexpression in various carcinomas highlights significant implications in tumor development and metastasis, making BTBD14B an important target for cancer research and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BTBD14B Antibody (E-3) References:
- Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1. | Korutla, L., et al. 2002. Neuroscience. 110: 421-9. PMID: 11906783
- The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. | Korutla, L., et al. 2005. J Neurochem. 94: 786-93. PMID: 16033423
- A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. | Nakayama, K., et al. 2006. Proc Natl Acad Sci U S A. 103: 18739-44. PMID: 17130457
- Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions. | Davidson, B., et al. 2007. Hum Pathol. 38: 1030-1036. PMID: 17391728
- NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. | Nakayama, K., et al. 2007. Cancer Res. 67: 8058-64. PMID: 17804717
- Expression of the bric-a-brac tramtrack broad complex protein NAC-1 in cervical carcinomas seems to correlate with poorer prognosis. | Yeasmin, S., et al. 2008. Clin Cancer Res. 14: 1686-91. PMID: 18347169
- A BTB/POZ gene, NAC-1, a tumor recurrence-associated gene, as a potential target for Taxol resistance in ovarian cancer. | Ishibashi, M., et al. 2008. Clin Cancer Res. 14: 3149-55. PMID: 18483383
- The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. | Zollman, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 10717-21. PMID: 7938017
- The POZ domain: a conserved protein-protein interaction motif. | Bardwell, VJ. and Treisman, R. 1994. Genes Dev. 8: 1664-77. PMID: 7958847
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BTBD14B Antibody (E-3) | sc-376216 | 200 µg/ml | $322.00 | |||
BTBD14B Antibody (E-3): m-IgG Fc BP-HRP Bundle | sc-552035 | 200 µg Ab; 10 µg BP | $361.00 | |||
BTBD14B Antibody (E-3) AC | sc-376216 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BTBD14B Antibody (E-3) HRP | sc-376216 HRP | 200 µg/ml | $322.00 | |||
BTBD14B Antibody (E-3) FITC | sc-376216 FITC | 200 µg/ml | $336.00 | |||
BTBD14B Antibody (E-3) PE | sc-376216 PE | 200 µg/ml | $349.00 | |||
BTBD14B Antibody (E-3) Alexa Fluor® 488 | sc-376216 AF488 | 200 µg/ml | $364.00 | |||
BTBD14B Antibody (E-3) Alexa Fluor® 546 | sc-376216 AF546 | 200 µg/ml | $364.00 | |||
BTBD14B Antibody (E-3) Alexa Fluor® 594 | sc-376216 AF594 | 200 µg/ml | $364.00 | |||
BTBD14B Antibody (E-3) Alexa Fluor® 647 | sc-376216 AF647 | 200 µg/ml | $364.00 | |||
BTBD14B Antibody (E-3) Alexa Fluor® 680 | sc-376216 AF680 | 200 µg/ml | $364.00 | |||
BTBD14B Antibody (E-3) Alexa Fluor® 790 | sc-376216 AF790 | 200 µg/ml | $364.00 |