BRL 44408 MALEATE (CAS 118343-19-4)

Zinc finger BTB domain containing (ZBTB) proteins are a family of transcription factors characterized by a distinct combination of zinc finger motifs and a BTB (Broad-Complex, Tramtrack, and Bric à brac) domain. The zinc finger motifs enable DNA binding, allowing these proteins to regulate the expression of target genes, while the BTB domain facilitates protein-protein interactions, often leading to the formation of multiprotein complexes. ZBTB proteins are involved in a wide range of cellular processes, including cell cycle regulation, differentiation, and development. The diverse functions of ZBTB proteins often involve interactions with chromatin remodeling complexes, influencing epigenetic landscapes. ZBTB proteins, such as ZBTB7A (Pokemon), play a significant role in oncogenesis, highlighting their importance in cell proliferation and apoptosis. The intricate balance in ZBTB signaling is crucial for maintaining normal cellular function, and dysregulation of this balance can lead to various pathologies. Targeting Zinc finger BTB domain containing (ZBTB) proteins for disruption or inhibition is a sophisticated approach that aims to modulate the function of these transcription factors, which play pivotal roles in numerous cellular processes. Given the diversity of functions ZBTB proteins perform, from gene regulation to involvement in development and cell differentiation, their inhibition or disruption can have far-reaching cellular consequences. Strategies for targeting ZBTB proteins would likely focus on disrupting their DNA-binding capability or interfering with their interactions with other proteins, particularly within chromatin remodeling complexes.