Molecular structure of BML-267
BML-267
Alternate Names:
6-Methyl-2-(oxalylamino)-4,5,6,7-tetrahydrothieno[2, 3-c]pyridine-3-carboxylic acid trifluoroacetic acid salt
Application:
BML-267 is a potent and selective protein tyrosine phosphatase 1B (PTP1B) inhibitor
Purity:
≥95%
Molecular Weight:
398.31
Molecular Formula:
C11H12N2O5S•C2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BML-267 is a potent and selective PTP1B (protein tyrosine phosphatase 1B) inhibitor (IC50=11 muM)1. A similar N-des-methyl analog has been reported and has been used to probe the mechanism of PTP1B-mediated inhibition of leptin signaling. BML-267 have limited cell permeability. A cell permeable diethyl ester prodrug of BML-267 compound is available.
BML-267 References
- Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. | Iversen, LF., et al. 2000. J Biol Chem. 275: 10300-7. PMID: 10744717
- Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. | Andersen, HS., et al. 2002. J Med Chem. 45: 4443-59. PMID: 12238924
- Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. | Lund, IK., et al. 2005. J Mol Endocrinol. 34: 339-51. PMID: 15821101
- Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization. | Chen, JR., et al. 2017. Molecules. 22: PMID: 29186901
- Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress‑impaired endothelial cell angiogenic response: A critical role for cell survival. | Abdelsalam, SS., et al. 2021. Mol Med Rep. 24: PMID: 34296297
- Myeloid-Specific PTP1B Deficiency Attenuates Inflammation-Induced and Ovariectomy-Induced Bone Loss in Mice by Inhibiting Osteoclastogenesis. | Kim, HJ., et al. 2022. J Bone Miner Res. 37: 505-514. PMID: 34812548
Inhibitor of:
Enzyme, and PTP1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BML-267, 10 mg | sc-205605 | 10 mg | $120.00 | |||
BML-267, 50 mg | sc-205605A | 50 mg | $497.00 |