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BML-267 is a potent and selective PTP1B (protein tyrosine phosphatase 1B) inhibitor (IC50=11 μM)1. A similar N-des-methyl analog has been reported and has been used to probe the mechanism of PTP1B-mediated inhibition of leptin signaling. BML-267 have limited cell permeability. A cell permeable diethyl ester prodrug of BML-267 compound is available.
1. Iversen, L.F., et al. 2000. J. Biol. Chem. 275: 10300-10305. PMID: 10744717
2. Andersen, H.S., et al. 2002. J. Med. Chem. 45: 4443-4459. PMID: 12238924
3. Lund, I.K., et al. 2005. J. Mol. Endocrinol. 34: 339-351. PMID: 15821101
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