Blood Group A1, A2, A3 antigen Antibody (Z2B-1): sc-52367

Blood Group A1, A2, A3 antigen Antibody (Z2B-1) is a mouse monoclonal IgM antibody that detects the Blood Group A1, A2, A3 antigen protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Blood Group A1, A2, A3 antigen monoclonal antibody (Z2B-1) is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing versatility for different experimental needs. Blood Group A1, A2, A3 antigen (Z2B-1) antibody plays a crucial role in studying immune response and cell recognition, as Blood Group A1, A2, A3 antigen is involved in the modulation of cell surface glycoproteins that influence cellular interactions and signaling pathways. These antigens are primarily located on erythrocytes and certain epithelial cells, where they contribute to the blood group classification system and are essential for transfusion compatibility. Notably, the expression of these antigens can change during malignant transformation, which may have implications for cancer diagnostics and therapeutics. The complexity of blood group antigens, including the interrelated specificities such as A (1 and 2), B, and H antigens, highlights their importance in both basic research and clinical applications, making Blood Group A1, A2, A3 (Z2B-1) monoclonal antibody a valuable tool for studying these critical biological processes.

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Blood Group A1, A2, A3 antigen Antibody (Z2B-1) References:

1. PLTs of blood group A1 donors express increased surface A antigen owing to apheresis and prolonged storage.  |  Julmy, F., et al. 2003. Transfusion. 43: 1378-85. PMID: 14507268
2. Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum.  |  Chung, WY., et al. 2005. Mol Biochem Parasitol. 144: 128-30. PMID: 16144724
3. Structural characterization of blood group A glycolipids in blood group A liver tissue in situ perfused with O blood: the dominating presence of type 1 core chain A antigens.  |  Samuelsson, BE., et al. 2006. Xenotransplantation. 13: 160-5. PMID: 16623812
4. Blood group A and B antigen expression in human kidneys correlated to A1/A2/B, Lewis, and secretor status.  |  Breimer, ME., et al. 2006. Transplantation. 82: 479-85. PMID: 16926591
5. Repetitive A epitope (type 3 chain A) defined by blood group A1-specific monoclonal antibody TH-1: chemical basis of qualitative A1 and A2 distinction.  |  Clausen, H., et al. 1985. Proc Natl Acad Sci U S A. 82: 1199-203. PMID: 2579390
6. Inhibition of the blood group A1 and A2 gene-specified N-acetyl-alpha-D-galactosaminyltransferases by uridine diphosphate D-galactose.  |  Race, C. and Watkins, WM. 1974. Carbohydr Res. 37: 239-44. PMID: 4429970
7. A-active trisaccharides isolated from A1 and A2 blood-group-specific glycoproteins.  |  Donald, AS. 1981. Eur J Biochem. 120: 243-9. PMID: 6172274
8. Another case of a lymphocytotoxic antibody with blood group A1 Leb and A Led associated specificity.  |  Staub Nielsen, L., et al. 1983. Tissue Antigens. 21: 177-83. PMID: 6190260
9. Trisaccharides from blood group A1 and A2 mucous glycoproteins.  |  Donald, AS. 1982. Adv Exp Med Biol. 144: 49-51. PMID: 7080941

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group A1, A2, A3 antigen Antibody (Z2B-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group A1, A2, A3 antigen Antibody (Z2B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group A1, A2, A3 antigen Antibody (Z2B-1) Specifications

Alternate Product Name: Blood Group A1, A2, A3 antigen

Product Clone Name: Z2B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Blood Group A1, A2, A3 antigen

Epitope Species: human

Product Reactivity/Detection: Blood Groups A1, A2 and A3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Blood Group A1, A2, A3 antigen Antibody (Z2B-1): FITC: Fluoroscein