Bisindolylmaleimide II CAS: 137592-45-1
MF: C27H26N4O2
MW: 438.5
An inhibitor of PKC and PDK1.

Bisindolylmaleimide II (CAS 137592-45-1)

Bisindolylmaleimide II | CAS 137592-45-1 is rated 5.0 out of 5 by 1.
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Synonym: 2-(1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl-3-(1H-indol-3-yl)maleimide
Application: An inhibitor of PKC and PDK1
CAS Number: 137592-45-1
Purity: ≥97% (mixture of two isomers)
Molecular Weight: 438.5
Molecular Formula: C27H26N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bisindolylmaleimide II is a general inhibitor of all PKC (protein kinase C) subtypes. This compound also inhibits PDK1 (IC50 = 14 μM), which is an important kinase in the insulin signaling pathway.

Physical State :
Solid
Solubility :
Soluble in ethanol, DMSO, and 100% ethanol.
Storage :
Store at -20° C
IC50 :
PDK1: IC50 = 14 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
2397
MDL Number :
MFCD00236430
SMILES :
CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

Download SDS (MSDS)

Certificate of Analysis

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Bisindolylmaleimide II  Product Citations

See how others have used Bisindolylmaleimide II. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 28039020  Abdelnabi, R. et al. 2017. Antiviral Res. 139: 79-87.

PMID: # 27660555  Ruedel, A. et al. 2016. Cancer Cell Int. 16: 71.

PMID: # 25087184  Limm, K. et al. 2014. Eur. J. Cancer. 50: 2714-24.

PMID: # 22228808  Diraimondo, TR. et al. 2012. J. Pharmacol. Exp. Ther. 341: 104-14.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Kuci Kuci , N. et al. (PubMed 16033962) reported that inhibition of PKC by Bisindolylmaleimide II prevents murine cytomegalovirus replication. -SCBT Publication Review
Date published: 2015-02-02
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