Date published: 2025-10-3

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Bis(methylthio)methane (CAS 1618-26-4)

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Alternate Names:
Dimethylthiomethane; Formaldehyde dimethyl mercaptal
CAS Number:
1618-26-4
Molecular Weight:
108.23
Molecular Formula:
C3H8S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bis(methylthio)methane is a chemical agent with multiple applications. It it used as an analytical tool for wastewater management and plays a role in producing isovaleric acid, a key intermediary for polyurethane creation. The compound displays unique conformational attributes and behaviors reminiscent of insoluble polymers. Research indicates its ability to hinder hepg2 cells in lab settings, having an IC50 value of 0.5 mM. The compound also showcases capabilities in asymmetric synthesis and is known for its ethyl formate-related radical neutralizing actions. Used extensively in scientific research, bis(methylthio)methane finds application in the crafting of rubber, aromas, and scents. Furthermore, it′s essential in deriving other organic sulfur compounds relevant to nanotech, biotech, and material science.


Bis(methylthio)methane (CAS 1618-26-4) References

  1. Truffle thio-flavours reversibly inhibit truffle tyrosinase.  |  Zarivi, O., et al. 2003. FEMS Microbiol Lett. 220: 81-8. PMID: 12644231
  2. One-dimensional coordination polymers incorporating silver(I) perfluorocarboxylate cuboctahedral clusters and the bis(methylthio)methane ligand.  |  Awaleh, MO., et al. 2007. Inorg Chem. 46: 3185-91. PMID: 17361998
  3. An asymmetric approach to 2-deoxynucleosides via organosulfur building blocks as chemical chameleons.  |  Trost, BM. and Nübling, C. 1990. Carbohydr Res. 202: 1-12. PMID: 2224884
  4. Molecular conformations and the liquid structure in bis(methylthio)methane and diethyl sulfide: diffraction experiments vs molecular dynamics simulations.  |  Gereben, O. and Pusztai, L. 2012. J Phys Chem B. 116: 9114-21. PMID: 22746696
  5. Conformational analysis of bis(methylthio)methane and diethyl sulfide molecules in the liquid phase: reverse Monte Carlo studies using classical interatomic potential functions.  |  Gereben, O. and Pusztai, L. 2013. J Phys Condens Matter. 25: 454201. PMID: 24140876
  6. Evaluation and application of static headspace-multicapillary column-gas chromatography-ion mobility spectrometry for complex sample analysis.  |  Denawaka, CJ., et al. 2014. J Chromatogr A. 1338: 136-48. PMID: 24630058
  7. Olfactometry Profiles and Quantitation of Volatile Sulfur Compounds of Swiss Tilsit Cheeses.  |  Fuchsmann, P., et al. 2015. J Agric Food Chem. 63: 7511-21. PMID: 26230142
  8. Multidimensional Gas Chromatography Coupled to Combustion-Isotope Ratio Mass Spectrometry/Quadrupole MS with a Low-Bleed Ionic Liquid Secondary Column for the Authentication of Truffles and Products Containing Truffle.  |  Sciarrone, D., et al. 2018. Anal Chem. 90: 6610-6617. PMID: 29733629
  9. Characterization of the Key Aroma Compounds in Three Truffle Varieties from China by Flavoromics Approach.  |  Feng, T., et al. 2019. Molecules. 24: PMID: 31514370
  10. RIFM fragrance ingredient safety assessment, bis-(methylthio)methane, CAS Registry Number 1618-26-4.  |  Api, AM., et al. 2021. Food Chem Toxicol. 153 Suppl 1: 112370. PMID: 34182041
  11. Irradiation-induced off-odour in chicken and its possible control.  |  Patterson, RL. and Stevenson, MH. 1995. Br Poult Sci. 36: 425-41. PMID: 7583374

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bis(methylthio)methane, 25 g

sc-252464
25 g
$92.00