Date published: 2026-5-4

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β-Lactose (CAS 5965-66-2)

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Alternate Names:
4-O-(β-D-Galactopyranosyl)-β-D-glucopyranose
Application:
β-Lactose is a sugar found in milk
CAS Number:
5965-66-2
Purity:
≥ 70% beta and ≤ 30% alpha
Molecular Weight:
342.30
Molecular Formula:
C12H22O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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β-Lactose, distinguished from its isomer α-lactose by the orientation of the glycosidic bond linking its glucose and galactose monomers, is a prime subject in the exploration of carbohydrate chemistry and enzymatic specificity. This disaccharide′s configuration allows it to be more soluble in water than its alpha counterpart, making it particularly relevant in studies of sugar solubility and crystallization processes. In research, β-lactose serves as a critical model compound for understanding the kinetics and mechanisms of lactase (β-galactosidase) activity, an enzyme that catalyzes the hydrolysis of lactose into its constituent sugars. This process is fundamental not only in the digestion of dairy products but also in the industrial production of lactose-free foods and in the biotechnological sector, where lactose serves as a substrate for fermentation processes. Additionally, the behavior of β-lactose in various conditions contributes to the study of the physical chemistry of sugars, including their role in the glass transition and crystallization phenomena, which are essential for food science and pharmaceutical research. The study of β-lactose and its interaction with other molecules also advances the understanding of molecular recognition processes, which are for the development of biosensors and drug delivery systems.


β-Lactose (CAS 5965-66-2) References

  1. Single-step granulation/tabletting of different grades of lactose: a comparison with high shear granulation and compression.  |  Keleb, EI., et al. 2004. Eur J Pharm Biopharm. 58: 77-82. PMID: 15207540
  2. Release of indomethacin from ultrasound dry granules containing lactose-based excipients.  |  Cavallari, C., et al. 2005. J Control Release. 102: 39-47. PMID: 15653132
  3. Assessing the re-crystallization behaviour of amorphous lactose using the RH-perfusion cell.  |  Timmermann, IL., et al. 2006. Eur J Pharm Biopharm. 64: 107-14. PMID: 16527465
  4. Simulation of roller compaction with subsequent tableting and characterization of lactose and microcrystalline cellulose.  |  Hein, S., et al. 2008. Pharm Dev Technol. 13: 523-32. PMID: 18728996
  5. The compressibility and compactibility of different types of lactose.  |  Ilić, I., et al. 2009. Drug Dev Ind Pharm. 35: 1271-80. PMID: 19466896
  6. The effect of engineered mannitol-lactose mixture on dry powder inhaler performance.  |  Kaialy, W., et al. 2012. Pharm Res. 29: 2139-56. PMID: 22477070
  7. Liquid crystalline phase as a probe for crystal engineering of lactose: carrier for pulmonary drug delivery.  |  Patil, SS., et al. 2015. Eur J Pharm Sci. 68: 43-50. PMID: 25460546
  8. Variability in the α and β anomer content of commercially available lactose.  |  Altamimi, MJ., et al. 2019. Int J Pharm. 555: 237-249. PMID: 30395957
  9. Individual and combined effect of pH and whey proteins on lactose crystallization.  |  Sánchez-García, YI., et al. 2019. Food Res Int. 116: 455-461. PMID: 30716968
  10. Phenomenological study of the synthesis of pure anhydrous β-lactose in alcoholic solution.  |  Lara-Mota, EE., et al. 2021. Food Chem. 340: 128054. PMID: 33017700
  11. Effect of probiotic Minas Frescal cheese on the volatile compound and metabolic profiles assessed by nuclear magnetic resonance spectroscopy and chemometric tools.  |  Balthazar, CF., et al. 2021. J Dairy Sci. 104: 5133-5140. PMID: 33663866
  12. Mutarotation and solubility of lactose as affected by carrageenans.  |  Sánchez-García, YI., et al. 2021. Food Res Int. 142: 110204. PMID: 33773679
  13. Investigating the stabilisation of IFN-α2a by replica exchange molecular dynamics simulation.  |  Li, D., et al. 2022. J Mol Model. 28: 232. PMID: 35882698
  14. A study of solid-state epimerisation within lactose powders and implications for milk derived ingredients stored in simulated tropical environmental zones.  |  Alzoubi, T., et al. 2023. Food Chem. 402: 134206. PMID: 36162173
  15. Metabolomics Integrated with HPLC-MS Reveals the Crucial Antioxidant Compounds of Muscadine Wine.  |  Xue, F., et al. 2022. Antioxidants (Basel). 12: PMID: 36670917

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

β-Lactose, 100 g

sc-221827
100 g
$133.00

β-Lactose, 500 g

sc-221827A
500 g
$367.00