β-Funaltrexamine hydrochloride (CAS 72786-10-8)
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β-Funaltrexamine hydrochloride is a derivative of naloxone. This compound is characterized by the addition of a funaltrexamine group to the naloxone molecule. β-Funaltrexamine hydrochloride is a selective mu-opioid receptor (MOR) antagonist. The mu-opioid receptor is a member of the opioid family of G-protein-coupled receptors. Primarily, β-Funaltrexamine hydrochloride is utilized in biochemical research to investigate the functioning of opioid receptors, including their role in signal transduction mechanisms within the central nervous system. Its high affinity and specificity for opioid receptors allow researchers to study the effects of blocking these receptors. Furthermore, the irreversible binding nature of β-Funaltrexamine hydrochloride to opioid receptors makes it useful for distinguishing between different receptor subtypes and understanding their individual contributions to opioid effects.
β-Funaltrexamine hydrochloride (CAS 72786-10-8) References
- Delta-opioid receptor antagonist inhibits immunomodulation by Met-enkephalin analogs. | Singh, VK., et al. 1999. Neuroimmunomodulation. 6: 355-60. PMID: 10474054
- Immunomodulation by opioid peptidomimetic compound. | Narayan, P., et al. 2001. Neuroimmunomodulation. 9: 134-40. PMID: 11752886
- Effects of chronic administration of PL017 and beta-funaltrexamine hydrochloride on susceptibility of kainic acid-induced seizures in rats. | Liu, H., et al. 2004. Sheng Li Xue Bao. 56: 101-6. PMID: 14985838
- Opioid receptors and acetaminophen (paracetamol). | Raffa, RB., et al. 2004. Eur J Pharmacol. 503: 209-10. PMID: 15496316
- Structure and binding energy of anion-pi and cation-pi complexes: a comparison of MP2, RI-MP2, DFT, and DF-DFT methods. | Quiñonero, D., et al. 2005. J Phys Chem A. 109: 4632-7. PMID: 16833802
- Molecular dynamics study of polarizability anisotropy relaxation in aromatic liquids and its connection with local structure. | Elola, MD. and Ladanyi, BM. 2006. J Phys Chem B. 110: 15525-41. PMID: 16884276
- Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain. | Wang, JY., et al. 2008. Neurochem Res. 33: 2134-41. PMID: 18473169
- A generalized formulation of ion-π electron interactions: role of the nonelectrostatic component and probe of the potential parameter transferability. | Albertí, M., et al. 2010. J Phys Chem A. 114: 11964-70. PMID: 20945865
- Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat. | Bobeck, EN., et al. 2012. J Pain. 13: 799-807. PMID: 22766006
- A new synthetic strategy for catechin-class polyphenols: concise synthesis of (-)-epicatechin and its 3-O-gallate. | Stadlbauer, S., et al. 2012. Chem Commun (Camb). 48: 8425-7. PMID: 22790234
- Accurate, precise, and efficient theoretical methods to calculate anion-π interaction energies in model structures. | Mezei, PD., et al. 2015. J Chem Theory Comput. 11: 360-71. PMID: 26574231
- Empirical Analysis of Optical Kerr Effect Spectra: A Case for Constraint. | Bender, JS., et al. 2017. J Phys Chem B. 121: 11376-11382. PMID: 29161049
- Possible involvement of the peripheral Mu-opioid system in antinociception induced by bergamot essential oil to allodynia after peripheral nerve injury. | Komatsu, T., et al. 2018. Neurosci Lett. 686: 127-132. PMID: 30201308
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Funaltrexamine hydrochloride, 2 mg | sc-362050 | 2 mg | $463.00 | |||
β-Funaltrexamine hydrochloride, 10 mg | sc-362050A | 10 mg | $1569.00 |