Molecular structure of Bepridil hydrochloride, CAS Number: 74764-40-2
Bepridil hydrochloride (CAS 74764-40-2)
See product citations (2)
Alternate Names:
1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride
Application:
Bepridil hydrochloride is a calcium channel protein inhibitor
CAS Number:
74764-40-2
Purity:
≥98%
Molecular Weight:
403.00
Molecular Formula:
C24H34N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bepridil hydrochloride is a calcium channel protein inhibitor and antagonist that increases the surface area of red blood cells. Bepridil hydrochloride may act to be a stomatocytic agent that causes endocytosis and lowers cell deformability in deoxygenated sickle erythrocytes. Furthermore, Bepridil hydrochloride has been reported to block Na+ and Ca2+ exchange through membranes. Bepridil hydrochloride also demonstrates the ability to act as an effective inhibitor of in vitro cell proliferation. Bepridil hydrochloride is an inhibitor of NCX.
Bepridil hydrochloride (CAS 74764-40-2) References
- An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard. | Noda, K., et al. 2011. J Chromatogr Sci. 49: 519-23. PMID: 21801483
- Bepridil hydrochloride alters potential-dependent and receptor-operated calcium channels in vascular smooth muscle of rabbit aorta. | Flaim, SF., et al. 1985. J Pharmacol Exp Ther. 234: 63-71. PMID: 2409274
- Effects of bepridil hydrochloride on cardiocirculatory dynamics, coronary vascular resistance, and cardiac output distribution in normal, conscious rats. | Flaim, SF., et al. 1988. J Cardiovasc Pharmacol. 11: 363-72. PMID: 2452931
- Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes. | Galizzi, JP., et al. 1986. J Biol Chem. 261: 1393-7. PMID: 3003067
- Efficacy of hybrid therapy using prior administration of bepridil hydrochloride and cryoballoon ablation in patients with persistent atrial fibrillation. | Yakabe, D., et al. 2020. J Cardiol. 75: 360-367. PMID: 31540839
- Effects of bepridil on the electrophysiologic properties of isolated canine and rabbit myocardial fibers. | Kato, R. and Singh, BN. 1986. Am Heart J. 111: 271-9. PMID: 3484892
- Hemodynamic effects of intravenous bepridil in patients with normal left ventricular function. | Alpert, JS., et al. 1985. Am J Cardiol. 55: 20C-24C. PMID: 3872053
- Pharmacokinetics and metabolism of bepridil. | Benet, LZ. 1985. Am J Cardiol. 55: 8C-13C. PMID: 3872057
- Electrophysiologic, hemodynamic and metabolic effects of intravenous bepridil hydrochloride. | Upward, JW., et al. 1985. Am J Cardiol. 55: 1589-95. PMID: 3873868
- Effects of hemodialysis on plasma protein binding of bepridil. | Pritchard, JF., et al. 1995. J Clin Pharmacol. 35: 137-41. PMID: 7751422
- Intracellular Ca2+ mediates the cytotoxicity induced by bepridil and benzamil in human brain tumor cells. | Lee, YS., et al. 1995. Cancer Lett. 88: 87-91. PMID: 7850778
- Bepridil as an antisickling agent: membrane internalization and cell rigidity. | Johnson, RM., et al. 1994. Am J Hematol. 46: 310-8. PMID: 8037182
Inhibitor of:
Calcium Channel Protein, calsequestrin 2, MYL7, NCX, neurocalcin, PCP-4, PMCA4, sorcin, TMIE, and Troponin C.Activator of:
Ebola virus VP40, and NCX1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bepridil hydrochloride, 10 mg | sc-202974 | 10 mg | $52.00 | |||
Bepridil hydrochloride, 25 mg | sc-202974A | 25 mg | $104.00 |