Molecular structure of Azithromycin Dihydrate, CAS Number: 117772-70-0
Azithromycin Dihydrate (CAS 117772-70-0)
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Alternate Names:
N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A,
Application:
Azithromycin Dihydrate is an azalide antimicrobial agent active in vitro against various pathogens
CAS Number:
117772-70-0
Purity:
>98%
Molecular Weight:
785.02
Molecular Formula:
C38H72N2O12•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Azithromycin dihydrate is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Azithromycin dihydrate is effective against a wide range of gram-positive and gram-negative bacteria, as well as atypical pathogens. The mechanism of action of azithromycin dihydrate involves the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. This results in the prevention of translocation of tRNA, leading to the disruption of protein synthesis and ultimately bacterial cell death.
Azithromycin Dihydrate (CAS 117772-70-0) References
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- Resistance to antimicrobials used for therapy of otitis media and sinusitis: effect of previous antimicrobial therapy and smoking. | Brook, I. and Gober, AE. 1999. Ann Otol Rhinol Laryngol. 108: 645-7. PMID: 10435921
- Synthesis of 9-deoxo-9a-aza-9a-homoerythromycin A 11,12-Hydrogen Borate and Azithromycin 11,12-Hydrogen Borate. A New Procedure to Obtain Azithromycin Dihydrate. | Bayod-Jasanada, M., et al. 1997. J Org Chem. 62: 7479-7481. PMID: 11671869
- Spectrofluorimetric analysis of certain macrolide antibiotics in bulk and pharmaceutical formulations. | Khashaba, PY. 2002. J Pharm Biomed Anal. 27: 923-32. PMID: 11836056
- Concentrations of erythromycin and azithromycin in mature Chinook salmon Oncorhynchus tshawytscha after intraperitoneal injection, and in their progeny. | Fairgrieve, WT., et al. 2006. Dis Aquat Organ. 68: 227-34. PMID: 16610588
- Degradation studies of azithromycin and its spectrophotometric determination in pharmaceutical dosage forms. | Sultana, N., et al. 2006. Pak J Pharm Sci. 19: 98-103. PMID: 16751118
- A validated spectrofluorometric assay for the determination of certain macrolide antibiotics in pharmaceutical formulations and spiked biological fluids. | El-Rabbat, N., et al. 2006. J AOAC Int. 89: 1276-87. PMID: 17042176
- Spectrophotometric determination of four macrolide antibiotics in pharmaceutical formulations and biological fluids via binary complex formation with eosin [corrected]. | Walash, MI., et al. 2007. J AOAC Int. 90: 1579-87. PMID: 18193735
- Occupational airborne contact dermatitis from azithromycin. | López-Lerma, I., et al. 2009. Clin Exp Dermatol. 34: e358-9. PMID: 19486052
- Development, characterization and solubility study of solid dispersions of azithromycin dihydrate by solvent evaporation method. | Arora, SC., et al. 2010. J Adv Pharm Technol Res. 1: 221-8. PMID: 22247849
- pH-Dependent stability of azithromycin in aqueous solution and structure identification of two new degradation products. | Saita, MG., et al. 2018. J Pharm Biomed Anal. 158: 47-53. PMID: 29860178
- Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles. | Bhattacharyya, S. and Reddy, P. 2019. Turk J Pharm Sci. 16: 425-431. PMID: 32454745
- Authentication of Antibiotics Using Portable Near-Infrared Spectroscopy and Multivariate Data Analysis. | Assi, S., et al. 2021. Appl Spectrosc. 75: 434-444. PMID: 32830991
- Enhancing Dissolution Rate and Antibacterial Efficiency of Azithromycin through Drug-Drug Cocrystals with Paracetamol. | Ul Islam, N., et al. 2021. Antibiotics (Basel). 10: PMID: 34438989
- Azithromycin. A review of its use in paediatric infectious diseases. | Langtry, HD. and Balfour, JA. 1998. Drugs. 56: 273-97. PMID: 9711451
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azithromycin Dihydrate, 250 mg | sc-210854 | 250 mg | $214.00 |