Molecular structure of AT-101, CAS Number: 90141-22-3
AT-101 (CAS 90141-22-3)
Alternate Names:
Gossypol (−)-Gossypol Pogosin (+)-Gossypol Tash 1 (R)-Gossypol (R)-(−)-Gossypol
CAS Number:
90141-22-3
Molecular Weight:
518.55
Molecular Formula:
C30H30O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
AT-101 (CAS 90141-22-3) References
- AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. | Zerp, SF., et al. 2009. Radiat Oncol. 4: 47. PMID: 19852810
- AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. | Moretti, L., et al. 2010. J Thorac Oncol. 5: 680-7. PMID: 20354451
- Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol). | Uzunoglu, S., et al. 2010. Toxicol Mech Methods. 20: 482-6. PMID: 20843265
- AT-101 inhibits hedgehog pathway activity and cancer growth. | Wang, J., et al. 2015. Cancer Chemother Pharmacol. 76: 461-9. PMID: 26113054
- AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells. | Yurekli, BS., et al. 2018. J Endocrinol Invest. 41: 233-240. PMID: 28730425
- AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. | Meyer, N., et al. 2018. Autophagy. 14: 1693-1709. PMID: 29938581
- AT‑101 induces G1/G0 phase arrest via the β‑catenin/cyclin D1 signaling pathway in human esophageal cancer cells. | Que, F., et al. 2019. Oncol Rep. 41: 1415-1423. PMID: 30483745
- Trastuzumab in combination with AT-101 induces cytotoxicity and apoptosis in Her2 positive breast cancer cells. | Bulut, G., et al. 2020. Future Oncol. 16: 4485-4495. PMID: 31829029
- Induction of apoptosis in human hormone-refractory prostate cancer cell lines by using resveratrol in combination with AT-101. | Aktepe, N. and Yukselten, Y. 2022. Andrologia. 54: e14267. PMID: 34633104
- Cyclic RGD-Decorated Liposomal Gossypol AT-101 Targeting for Enhanced Antitumor Effect. | Liu, H., et al. 2022. Int J Nanomedicine. 17: 227-244. PMID: 35068931
Inhibitor of:
Apoptosis Repressor with CARD (ARC), Bcl-2, Bcl-w, Bcl-xl, Bclp2, Bfk, BID, BNIP-3, EG229862, and PUMA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AT-101, 10 mg | sc-507316 | 10 mg | $160.00 |