Molecular structure of Apelin-13, CAS Number: 217082-58-1
Apelin-13 (CAS 217082-58-1)
See product citations (19)
Alternate Names:
Apelin-13 is also known as Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe.
Application:
Apelin-13 is a 13-amino acid polypeptide and endogenous ligand of the G-protein coupled receptor APJ.
CAS Number:
217082-58-1
Purity:
≥95%
Molecular Weight:
1550.83
Molecular Formula:
C69H111N23O16S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is an endogenous ligand of the APJ receptor, a G protein-coupled receptor (EC50 = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. However, unlike apelin-36, Apelin-13 is a poor blocker of HIV cell entry.
Apelin-13 (CAS 217082-58-1) References
- Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. | Habata, Y., et al. 1999. Biochim Biophys Acta. 1452: 25-35. PMID: 10525157
- Characterization of apelin, the ligand for the APJ receptor. | Lee, DK., et al. 2000. J Neurochem. 74: 34-41. PMID: 10617103
- Apelin peptides block the entry of human immunodeficiency virus (HIV). | Zou, MX., et al. 2000. FEBS Lett. 473: 15-8. PMID: 10802050
- Emerging roles of apelin in biology and medicine. | Kleinz, MJ. and Davenport, AP. 2005. Pharmacol Ther. 107: 198-211. PMID: 15907343
- PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions. | He, L., et al. 2019. J Cell Physiol. 234: 8668-8682. PMID: 30456860
- Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling. | Duan, J., et al. 2019. J Neuroinflammation. 16: 24. PMID: 30709405
- Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway. | Luo, H., et al. 2019. Front Pharmacol. 10: 395. PMID: 31040784
- Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats. | Xu, W., et al. 2019. J Neuroinflammation. 16: 247. PMID: 31791369
- Apelin-13 prevents hippocampal synaptic plasticity impairment in Parkinsonism rats. | Esmaeili-Mahani, S., et al. 2021. J Chem Neuroanat. 111: 101884. PMID: 33161074
- Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury. | Shao, ZQ., et al. 2021. Neural Regen Res. 16: 1044-1051. PMID: 33269749
- Apelin-13 induces mitophagy in bone marrow mesenchymal stem cells to suppress intracellular oxidative stress and ameliorate osteoporosis by activation of AMPK signaling pathway. | Chen, L., et al. 2021. Free Radic Biol Med. 163: 356-368. PMID: 33385540
- Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism. | Sturny, M., et al. 2021. J Sex Med. 18: 875-888. PMID: 33863684
- Apelin-13 protects human neuroblastoma SH-SY5Y cells against amyloid-beta induced neurotoxicity: Involvement of anti oxidant and anti apoptotic properties. | Samandari-Bahraseman, MR. and Elyasi, L. 2022. J Basic Clin Physiol Pharmacol. 33: 599-605. PMID: 33977683
- Apelin-13-Mediated AMPK ameliorates endothelial barrier dysfunction in acute lung injury mice via improvement of mitochondrial function and autophagy. | Kong, X., et al. 2021. Int Immunopharmacol. 101: 108230. PMID: 34655850
- Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. | Tatemoto, K., et al. 1998. Biochem Biophys Res Commun. 251: 471-6. PMID: 9792798
Activator of:
Apelin Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apelin-13, 1 mg | sc-351718 | 1 mg | $98.00 | |||
Apelin-13, 5 mg | sc-351718A | 5 mg | $405.00 | |||
Apelin-13, 10 mg | sc-351718B | 10 mg | $619.00 | |||
Apelin-13, 25 mg | sc-351718C | 25 mg | $1348.00 |