Anidulafungin (CAS 166663-25-8)

Anidulafungin is a semisynthetic echinocandin antifungal agent derived from a fermentation product of Aspergillus nidulans. Research on Anidulafungin has predominantly focused on its mechanism of action and its role in combating fungal infections, particularly those caused by Candida species. Mechanistically, Anidulafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, by specifically targeting the enzyme 1,3-β-D-glucan synthase. This inhibition leads to the disruption of cell wall integrity, osmotic instability, and ultimately fungal cell death. In research settings, Anidulafungin has been utilized to study fungal cell wall biosynthesis, explain the mechanisms of echinocandin resistance, and explore synergistic interactions with other antifungal agents. Additionally, Anidulafungin has been investigated for its potential applications in antifungal prophylaxis and research of invasive fungal infections in immunocompromised patients. Furthermore, studies have focused on optimizing dosing regimens, evaluating pharmacokinetic properties, and assessing the safety profile of Anidulafungin in various research contexts. Overall, Anidulafungin represents a valuable research tool in the ongoing efforts to understand and combat fungal infections.