Date published: 2026-3-3

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Anhydrotetracycline (CAS 1665-56-1)

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Alternate Names:
4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide
CAS Number:
1665-56-1
Purity:
≥95%
Molecular Weight:
426.42
Molecular Formula:
C22H22N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Anhydrotetracycline is a compound that plays a significant role in molecular biology research. It is utilized as an inducer in the study of gene expression systems that are regulated by tetracycline-controlled transcriptional activators. Researchers use anhydrotetracycline to activate or repress the expression of target genes, allowing for the controlled investigation of gene function and protein production in various types of cells. Moreover, it is involved in the study of bacterial resistance mechanisms, providing insights into how tetracycline antibiotics interact with bacterial ribosomes and affect protein synthesis. Anhydrotetracycline is also used in the development of biosensors, where it serves as a ligand that can be detected upon binding to its specific receptors, which is useful in the detection of tetracycline-responsive regulatory systems.


Anhydrotetracycline (CAS 1665-56-1) References

  1. Spectrofluorimetric determination of tetracycline and anhydrotetracycline in serum and urine.  |  Chang, WB., et al. 1992. Analyst. 117: 1377-8. PMID: 1443636
  2. How does Mg(2+) affect the binding of anhydrotetracycline in the TetR protein?  |  Leypold, CF., et al. 2004. Photochem Photobiol Sci. 3: 109-19. PMID: 14768626
  3. Tet repressor residues indirectly recognizing anhydrotetracycline.  |  Schubert, P., et al. 2004. Eur J Biochem. 271: 2144-52. PMID: 15153105
  4. Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.  |  Zhang, W., et al. 2008. J Am Chem Soc. 130: 6068-9. PMID: 18422316
  5. Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems.  |  Lochner, S., et al. 2010. Bioorg Med Chem. 18: 6127-33. PMID: 20638851
  6. Binding of the highly toxic tetracycline derivative, anhydrotetracycline, to bovine serum albumin.  |  Burgos, MI., et al. 2011. Biol Pharm Bull. 34: 1301-6. PMID: 21804222
  7. A synthetic anhydrotetracycline-controllable gene expression system in Ralstonia eutropha H16.  |  Li, H. and Liao, JC. 2015. ACS Synth Biol. 4: 101-6. PMID: 24702232
  8. Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control.  |  Baumschlager, A., et al. 2020. Nat Commun. 11: 3834. PMID: 32737309
  9. Determination of tetracycline hydrochloride in presence of anhydrotetracycline by differential pulse polarography.  |  Sabharwal, S., et al. 1988. J Pharm Sci. 77: 78-80. PMID: 3346827
  10. Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.  |  Kumar, H., et al. 2023. Commun Biol. 6: 423. PMID: 37062778
  11. Metal complexes of anhydrotetracycline. 1. A spectrometric study of the Cu(II) and Ni(II) complexes.  |  de Siqueira, JM., et al. 1994. J Pharm Sci. 83: 291-5. PMID: 8207670
  12. Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells.  |  Gossen, M. and Bujard, H. 1993. Nucleic Acids Res. 21: 4411-2. PMID: 8415012
  13. Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements.  |  Lutz, R. and Bujard, H. 1997. Nucleic Acids Res. 25: 1203-10. PMID: 9092630
  14. Conformational analysis of the anhydrotetracycline molecule: a toxic decomposition product of tetracycline.  |  Dos Santos, HF., et al. 1998. J Pharm Sci. 87: 190-5. PMID: 9519152
  15. A theoretical study of the interaction of anhydrotetracycline with Al(III).  |  De Almeida, WB., et al. 1998. J Pharm Sci. 87: 1101-8. PMID: 9724562

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Anhydrotetracycline, 2.5 mg

sc-481048
2.5 mg
$320.00