Molecular structure of Andrastin A
Andrastin A (CAS 174232-42-9)
See product citations (3)
Alternate Names:
Methyl-3-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylate
Application:
Andrastin A is a mycotoxin, FT inhibitor, and anticancer compound
CAS Number:
174232-42-9
Molecular Weight:
486.60
Molecular Formula:
C28H38O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Andrastin A is a mycotoxin that is also an protein FT (farnesyltransferase (PFTase)) inhibitor, anti-cancer compound, and directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells. it is believed to act as an inhibitor of several different enzymes, including cyclooxygenase, lipoxygenase, and phospholipase A2. Additionally, it is believed to act as an inhibitor of the enzyme nitric oxide synthase, which is responsible for the production of nitric oxide in the body.
Andrastin A (CAS 174232-42-9) References
- Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications. | Overy, DP., et al. 2005. Mycol Res. 109: 1243-9. PMID: 16279417
- Mycotoxins and other secondary metabolites produced in vitro by Penicillium paneum Frisvad and Penicillium roqueforti Thom isolated from baled grass silage in Ireland. | O'Brien, M., et al. 2006. J Agric Food Chem. 54: 9268-76. PMID: 17117820
- Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeón and Bejes-Tresviso local varieties of blue-veined cheeses. | Fernández-Bodega, MA., et al. 2009. Int J Food Microbiol. 136: 18-25. PMID: 19837474
- Multi-mycotoxin analysis of maize silage by LC-MS/MS. | Rasmussen, RR., et al. 2010. Anal Bioanal Chem. 397: 765-76. PMID: 20213172
- Secondary metabolites from Penicillium corylophilum isolated from damp buildings. | McMullin, DR., et al. 2014. Mycologia. 106: 621-8. PMID: 24891425
- Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold. | Matsuda, Y., et al. 2016. Org Lett. 18: 296-9. PMID: 26731665
- Enniatin B and beauvericin are common in Danish cereals and show high hepatotoxicity on a high-content imaging platform. | Svingen, T., et al. 2017. Environ Toxicol. 32: 1658-1664. PMID: 27628925
- Validation and application of a liquid chromatography-tandem mass spectrometry based method for the assessment of the co-occurrence of mycotoxins in maize silages from dairy farms in NW Spain. | Dagnac, T., et al. 2016. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 33: 1850-1863. PMID: 27707355
- The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. | Rojas-Aedo, JF., et al. 2017. Front Microbiol. 8: 813. PMID: 28529508
- Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster. | Fernández-Bodega, Á., et al. 2017. Appl Microbiol Biotechnol. 101: 6111-6121. PMID: 28620689
- Role of sfk1 Gene in the Filamentous Fungus Penicillium roqueforti. | Torrent, C., et al. 2017. Front Microbiol. 8: 2424. PMID: 29270163
- The developmental regulator Pcz1 affects the production of secondary metabolites in the filamentous fungus Penicillium roqueforti. | Rojas-Aedo, JF., et al. 2018. Microbiol Res. 212-213: 67-74. PMID: 29853169
- Fungal Diversity and Mycotoxins in Low Moisture Content Ready-To-Eat Foods in Nigeria. | Ezekiel, CN., et al. 2020. Front Microbiol. 11: 615. PMID: 32328050
- Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis. | Uchida, R., et al. 1996. J Antibiot (Tokyo). 49: 418-24. PMID: 8682717
- Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells. | Rho, MC., et al. 1998. J Antibiot (Tokyo). 51: 68-72. PMID: 9531989
Inhibitor of:
FT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Andrastin A, 250 µg | sc-396450 | 250 µg | $62.00 | |||
Andrastin A, 1 mg | sc-396450A | 1 mg | $256.00 |