Amoxapine-d8 (CAS 1189671-27-9)
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Amoxapine-d8, a synthetic, labelled derivative of the tricyclic compound amoxapine, has proven valuable in research laboratories for multiple purposes. It stands as a stable, non-toxic, and non-volatile compound. Mechanistically, amoxapine-d8 shares similarities with its parent compound, amoxapine. It operates by impeding the reuptake of serotonin and norepinephrine within the brain. This blockade ultimately results in elevated levels of these neurotransmitters. The incorporation of deuterium atoms into a molecule like amoxapine can enhance its stability against metabolic degradation, allowing for more precise and detailed study of its kinetic profile. In mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, the presence of deuterium allows for the clear differentiation of the labeled compound from its unlabeled counterpart.
Amoxapine-d8 (CAS 1189671-27-9) References
- Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers. | Spyker, DA., et al. 2010. J Clin Pharmacol. 50: 169-79. PMID: 19915181
- Multiple dose pharmacokinetics of inhaled loxapine in subjects on chronic, stable antipsychotic regimens. | Spyker, DA., et al. 2015. J Clin Pharmacol. 55: 985-94. PMID: 25808074
- Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice. | Inoue, Y., et al. 2022. J Toxicol Sci. 47: 99-108. PMID: 35236805
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amoxapine-d8, 1 mg | sc-217638 | 1 mg | $388.00 |