Molecular structure of AMG-208, CAS Number: 1002304-34-8
AMG-208 (CAS 1002304-34-8)
Alternate Names:
-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline
Application:
AMG-208 is a highly selective Met inhibitor (IC50 = 9.3 nM)
CAS Number:
1002304-34-8
Purity:
≥99%
Molecular Weight:
383.4
Molecular Formula:
C22H17N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
AMG-208 is a highly selective Met inhibitor (IC50 = 9.3 nM).
AMG-208 (CAS 1002304-34-8) References
- Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. | Albrecht, BK., et al. 2008. J Med Chem. 51: 2879-82. PMID: 18426196
- A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. | Tiedt, R., et al. 2011. Cancer Res. 71: 5255-64. PMID: 21697284
- HGF/c-MET targeted therapeutics: novel strategies for cancer medicine. | Yap, TA., et al. 2011. Curr Drug Targets. 12: 2045-58. PMID: 21777195
- Targeting the HGF/Met signaling pathway in cancer therapy. | Cecchi, F., et al. 2012. Expert Opin Ther Targets. 16: 553-72. PMID: 22530990
- The c-Met inhibitors: a new class of drugs in the battle against advanced nonsmall-cell lung cancer. | Sgambato, A., et al. 2012. Curr Pharm Des. 18: 6155-68. PMID: 22873759
- MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedside. | Avan, A., et al. 2014. Curr Med Chem. 21: 975-89. PMID: 23992325
- Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. | Yang, Y., et al. 2017. Bioorg Chem. 70: 126-132. PMID: 28043720
- C-Met as a potential target for the treatment of gastrointestinal cancer: Current status and future perspectives. | Bahrami, A., et al. 2017. J Cell Physiol. 232: 2657-2673. PMID: 28075018
- The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade. | Liu, B., et al. 2019. J Exp Clin Cancer Res. 38: 455. PMID: 31694696
- Updates on the versatile quinoline heterocycles as anticancer agents. | Suliphuldevara Matada, Basavarajaiah, Nagesh Gunavanthrao Yernale, and Jeelan N. Basha. (2023): Physical Sciences Reviews. 8.9: 2243-2259.
Inhibitor of:
Met.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMG-208, 10 mg | sc-364399 | 10 mg | $645.00 | |||
AMG-208, 50 mg | sc-364399A | 50 mg | $1950.00 |