Amantadine-d15 Hydrochloride (CAS 665-66-7 (unlabeled))

Amantadine-d15 Hydrochloride, chemically distinguished by the substitution of fifteen hydrogen atoms with deuterium (D), is an isotopically labeled variant of amantadine hydrochloride. This modification significantly alters its physical properties, notably its vibrational modes, due to the increased mass of deuterium compared to hydrogen, which can be particularly advantageous in spectroscopic studies for elucidating the compound′s interaction mechanisms at the molecular level. In research, Amantadine-d15 Hydrochloride serves as a pivotal tool in the study of viral replication processes, especially in the context of the influenza A virus. It is employed to investigate the mechanisms by which viral particles penetrate host cellular membranes, offering a unique window into the dynamics of viral entry and uncoating. The isotopic labeling enhances the resolution of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry analyses, making it an indispensable compound for tracing the distribution and metabolic pathways of amantadine in complex biological systems without the interference of background signals from naturally occurring isotopes. This refined understanding aids in the development of antiviral strategies and the exploration of viral resistance mechanisms, providing a foundational platform for the synthesis of novel antiviral agents.