Alternariol CAS: 641-38-3
MF: C14H10O5
MW: 258.23
A mycotoxin with anti-proliferative activity.

Alternariol (CAS 641-38-3)

Alternariol | CAS 641-38-3 is rated 5.0 out of 5 by 1.
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Application: Alternariol is a mycotoxin with anti-proliferative activity
CAS Number: 641-38-3
Molecular Weight: 258.23
Molecular Formula: C14H10O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Alternariol, a mycotoxin, has been shown to inhibit the short action current across transepithelial sodium pumps. This compound has also demonstrated the ability to have acute cytotoxic effects on cells and cause a halt in cell proliferation. At high doses, alternariol has been reported to induce cell growth arrest in G2/M phase. Additional experiments suggest that alternariol interacts with DNA by intercalation and causes DNA damage. Alternariol is an inhibitor of AChE and BChE.


References

1. DiCosmo, F. and Straus, N.A. 1985. Experientia. 41: 1188-1190. PMID: 3899714
2. Micelli, S., et al. 1990. Gen. Pharmacol. 21: 617-620. PMID: 2276581
3. Zhao, J., et al. 2009. Wei Sheng Yan Jiu. 38: 133-135. PMID: 19408650

Physical State :
Solid
Derived From :
Alternaria sp.
Solubility :
Soluble in DMSO (~30 mg/ml), ethanol (~0.5 mg/ml), water (partly), acetone (2.20-2.80 mg/ml, clear, faint yellow to yellow), and DMF (~30 mg/ml).
Storage :
Store at -20° C
Melting Point :
205.88° C (Predicted)
Boiling Point :
586.89° C at 760 mmHg (Predicted)
Density :
1.56 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
IC50 :
ARK-2: IC50 = 1.63 µM (human); Flt-3/Flk-2: IC50 = 1.67 µM (human); ARK-1: IC50 = 2.83 µM (human); PDGFR-β: IC50 = 3.45 µM (human); Flk-1: IC50 = 3.56 µM (human)
pK Values :
pKa: 7.16 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HP8757000
PubChem CID :
5359485
MDL Number :
MFCD00133068
Beilstein Registry :
0244839
SMILES :
CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Alternariol (CAS 641-38-3)  Product Citations

See how others have used Alternariol (CAS 641-38-3). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27131905  Juan-García, A. et al. 2016. Toxicol In Vitro. 34: 264-73.

PMID: # 26802676  Fernández-Blanco, C. et al. 2016. Food Chem. Toxicol. 89: 60-6.

PMID: # 26581633  Fernández-Blanco, C. et al. 2016. Toxicol. Lett. 241: 38-48.

PMID: # 25772259  Juan-García, A. et al. 2015. Toxicol. Lett. 235: 8-16.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Solhaug Solhaug, A. et al. (PubMed 26341179) reported that the mycotoxin Alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses. -SCBT Publication Review
Date published: 2015-04-30
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