Molecular structure of Alternariol, CAS Number: 641-38-3
Alternariol (CAS 641-38-3)
See product citations (5)
Application:
Alternariol is a mycotoxin with anti-proliferative activity
CAS Number:
641-38-3
Molecular Weight:
258.23
Molecular Formula:
C14H10O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Alternariol, a mycotoxin, may act to inhibit the short action current across transepithelial sodium pumps. This compound has also demonstrated the ability to have acute cytotoxic effects on cells and cause a halt in cell proliferation. At high doses, alternariol has been reported to induce cell growth arrest in G2/M phase. Additional experiments suggest that alternariol interacts with DNA by intercalation and causes DNA damage. Alternariol is an inhibitor of AChE and BChE.
Alternariol (CAS 641-38-3) References
- [Acute cytotoxicity of alternariol on NIH/3T3 cells]. | Zhao, J., et al. 2009. Wei Sheng Yan Jiu. 38: 133-5. PMID: 19408650
- Stable isotope dilution assays of alternariol and alternariol monomethyl ether in beverages. | Asam, S., et al. 2009. J Agric Food Chem. 57: 5152-60. PMID: 19530709
- The effect of ADH and insulin on active sodium transport across frog skin in the presence of alternariol mycotoxin. | Micelli, S., et al. 1990. Gen Pharmacol. 21: 617-20. PMID: 2276581
- Mechanisms of Action and Toxicity of the Mycotoxin Alternariol: A Review. | Solhaug, A., et al. 2016. Basic Clin Pharmacol Toxicol. 119: 533-539. PMID: 27341187
- Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants. | Gruber-Dorninger, C., et al. 2017. J Agric Food Chem. 65: 7052-7070. PMID: 27599910
- Alternariol as virulence and colonization factor of Alternaria alternata during plant infection. | Wenderoth, M., et al. 2019. Mol Microbiol. 112: 131-146. PMID: 30947377
- Interaction of Mycotoxin Alternariol with Serum Albumin. | Fliszár-Nyúl, E., et al. 2019. Int J Mol Sci. 20: PMID: 31083629
- Alternariol disturbs oocyte maturation and preimplantation development. | Schoevers, EJ., et al. 2020. Mycotoxin Res. 36: 93-101. PMID: 31473931
- Interactions of Mycotoxin Alternariol with Cyclodextrins and its Removal from Aqueous Solution by Beta-Cyclodextrin Bead Polymer. | Fliszár-Nyúl, E., et al. 2019. Biomolecules. 9: PMID: 31480370
- Mycotoxin Alternariol (AOH) Affects Viability and Motility of Mammary Breast Epithelial Cells. | Kowalska, K., et al. 2021. Int J Mol Sci. 22: PMID: 33445675
- Alternariol exerts embryotoxic and immunotoxic effects on mouse blastocysts through ROS-mediated apoptotic processes. | Huang, CH., et al. 2021. Toxicol Res (Camb). 10: 719-732. PMID: 34484663
- Discovery of mycotoxin alternariol as a potential lead compound targeting xanthine oxidase. | Fan, J., et al. 2022. Chem Biol Interact. 360: 109948. PMID: 35430257
- Interactions of Mycotoxin Alternariol with Cytochrome P450 Enzymes and OATP Transporters. | Fliszár-Nyúl, E., et al. 2022. Metabolites. 13: PMID: 36676970
- Alternariol, a dibenzopyrone mycotoxin of Alternaria spp., is a new photosensitizing and DNA cross-linking agent. | DiCosmo, F. and Straus, NA. 1985. Experientia. 41: 1188-90. PMID: 3899714
Inhibitor of:
AChE, and BChE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Alternariol, 1 mg | sc-202923 | 1 mg | $131.00 |