Date published: 2026-4-30

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α-Methyl-D-serine (CAS 81132-44-7)

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Alternate Names:
(R)-(−)-2-Amino-3-hydroxy-2-methylpropionic Acid; 2-Methyl-D-serine; (−)-2-Methyl-D-serine; D-α-Methylserine
Application:
α-Methyl-D-serine is a chiral building block
CAS Number:
81132-44-7
Molecular Weight:
119.12
Molecular Formula:
C4H9NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A potential chiral building blocks for the synthesis of different α -methyl α -amino acids.


α-Methyl-D-serine (CAS 81132-44-7) References

  1. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.  |  Rew, Y., et al. 2002. J Med Chem. 45: 3746-54. PMID: 12166947
  2. Purification and gene cloning of alpha-methylserine aldolase from Ralstonia sp. strain AJ110405 and application of the enzyme in the synthesis of alpha-methyl-L-serine.  |  Nozaki, H., et al. 2008. Appl Environ Microbiol. 74: 7596-9. PMID: 18952881
  3. Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.  |  Muliandi, A., et al. 2014. Chem Biol. 21: 923-34. PMID: 25041948
  4. A three-component monooxygenase from Rhodococcus wratislaviensis may expand industrial applications of bacterial enzymes.  |  Hibi, M., et al. 2021. Commun Biol. 4: 16. PMID: 33398074
  5. An efficient and regioselective biocatalytic synthesis of aromatic N-oxides by using a soluble di-iron monooxygenase PmlABCDEF produced in the Pseudomonas species.  |  Petkevičius, V., et al. 2021. Microb Biotechnol. 14: 1771-1783. PMID: 34115446
  6. Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future.  |  Ivshina, I., et al. 2022. Front Microbiol. 13: 967127. PMID: 36246215
  7. Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor.  |  Powell, MM., et al. 2023. J Am Chem Soc. 145: 16526-16537. PMID: 37471626
  8. Racemization of the substrate and product by serine palmitoyltransferase from Sphingobacterium multivorum yields two enantiomers of the product from d-serine.  |  Ikushiro, H., et al. 2024. J Biol Chem. 300: 105728. PMID: 38325740

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

α-Methyl-D-serine, 50 mg

sc-217545
50 mg
$380.00