α-Dystrobrevin Antibody (23): sc-136129
- α-Dystrobrevin Antibody (23) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 249-403 of α-Dystrobrevin of mouse origin
- recommended for detection of all isoforms of α-Dystrobrevin of mouse and rat origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for α-Dystrobrevin Antibody (23). This work is in progress.
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α-Dystrobrevin Antibody (23) is a mouse monoclonal IgG1 antibody that detects α-Dystrobrevin in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). α-Dystrobrevin is a crucial component of the dystrophin glycoprotein complex, playing a significant role in maintaining the structural integrity of muscle cells and facilitating synapse maturation, which is vital for normal muscle function. α-Dystrobrevin is predominantly localized to the cytoplasmic side of the sarcolemma and is particularly concentrated at the neuromuscular junctions in skeletal muscle, where α-Dystrobrevin contributes to the transmission of signals between nerves and muscles. α-Dystrobrevin exists in endothelial and smooth muscle cells, and alternative splicing variants underscore diverse functional roles across different tissues. Notably, the insertion of 57 amino acids through alternative splicing results in the increased molecular mass of α-Dystrobrevin 1 in skeletal and cardiac muscle compared to expression in brain and lung tissues. Various isoforms, such as γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, highlight the complexity of regulation and function, making α-Dystrobrevin a critical target for understanding muscular dystrophies and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Dystrobrevin Antibody (23) | sc-136129 | 50 µg/0.5 ml | $322.00 |