Aerothionin (CAS 28714-26-3)

Aerothionin, catalogued under the CAS number 28714-26-3, is a bioactive compound classified as a bromotyrosine derivative, which is primarily found in marine sponges, such as those from the Aplysina genus. This compound exhibits a unique structural framework consisting of brominated aromatic groups, which are believed to play a crucial role in its biological activity. Aerothionin functions by interfering with cell membrane integrity and dynamics. Its mechanism involves the disruption of the lipid bilayer, potentially by inserting itself into membranes and altering their fluidity and permeability. This action can affect the normal physiological processes of cells, thereby modulating cellular functions such as communication, nutrient uptake, and defense mechanisms. In research contexts, aerothionin has been utilized to study cellular membrane processes and to explore the broader ecological roles of natural products in marine organisms, particularly their defensive strategies against predators and microbial invasion. By investigating the interactions of aerothionin with cellular membranes, researchers can gain insights into the fundamental principles governing cell membrane architecture and the potential of such compounds in modulating these structures. Through such studies, aerothionin contributes valuable knowledge to the fields of marine biology, chemical ecology, and biochemistry.