ADAMTS-3 Antibody (1H8): sc-517029

ADAMTS-3 Antibody (1H8) is a mouse monoclonal IgG1 kappa light chain antibody that detects the ADAMTS-3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ADAMTS-3 antibody (1H8) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. ADAMTS-3, a member of the ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) family, plays a crucial role in processing extracellular matrix components, particularly in cleaving type II procollagens, which is essential for maintaining cartilage integrity and function. ADAMTS-3 is primarily expressed in fetal tissues such as lung, kidney, and liver, and shows significantly higher expression in human cartilage, where the ratio of ADAMTS3 to ADAMTS2 mRNA is approximately 5:1. The unique structure of ADAMTS-3, which includes an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain, and three carboxy-terminal thrombospondin type-1 motifs, is vital for enzymatic activity and interactions with other proteins in the extracellular matrix. Understanding ADAMTS-3 function and regulation is important for elucidating its role in various pathological conditions, including arthritis and cancer, making ADAMTS-3 (1H8) antibody an invaluable research tool.

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ADAMTS-3 Antibody (1H8) References:

1. ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.  |  Tang, BL. and Hong, W. 1999. FEBS Lett. 445: 223-5. PMID: 10094461
2. ADAMTS: a novel family of extracellular matrix proteases.  |  Tang, BL. 2001. Int J Biochem Cell Biol. 33: 33-44. PMID: 11167130
3. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis.  |  Fernandes, RJ., et al. 2001. J Biol Chem. 276: 31502-9. PMID: 11408482
4. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.  |  Colige, A., et al. 2002. J Biol Chem. 277: 5756-66. PMID: 11741898
5. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.  |  Cal, S., et al. 2002. Gene. 283: 49-62. PMID: 11867212
6. Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells.  |  Alper, M., et al. 2015. Gene. 573: 321-7. PMID: 26232334
7. ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.  |  Yang, CY., et al. 2017. Osteoarthritis Cartilage. 25: 1000-1009. PMID: 28216310
8. Relevance of the Proteolytic Processing of Reelin by ADAMTS-3 in Brain Functions.  |  Lemarchant, S. 2017. J Neurosci. 37: 6814-6815. PMID: 28724754
9. Expression and Preparation of Recombinant Reelin and ADAMTS-3 Proteins.  |  Kohno, T., et al. 2020. Methods Mol Biol. 2043: 93-104. PMID: 31463905
10. [USF1 Suppresses Expression of Fibrillar Type I, II, and III Collagen and pNP Adamts-3 in Osteosarcoma Cells].  |  Alper, M., et al. 2021. Mol Biol (Mosk). 55: 634-642. PMID: 34432781
11. Hypoxic regulation of ADAMTS-2 and -3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1α in endothelial cells.  |  Altuntaş, C., et al. 2023. Mol Cell Biochem. 478: 1151-1160. PMID: 36241950
12. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Nagase, T., et al. 1997. DNA Res. 4: 141-50. PMID: 9205841

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADAMTS-3 Antibody (1H8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ADAMTS-3 Antibody (1H8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADAMTS-3 Antibody (1H8) Specifications

Alternate Product Name: ADAMTS3

Product Clone Name: 1H8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1048-1128

Epitope Target: ADAMTS-3

Epitope Species: human

Product Reactivity/Detection: ADAMTS-3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ADAMTS-3 Antibody (1H8): N/A