Date published: 2026-4-19

1-800-457-3801

SCBT Portrait Logo
Seach Input

Acyclovir-d4 (CAS 59277-89-3 (unlabeled))

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
2-Amino-9-[(1,1,2,2-tetradeuterio-2-hydroxyethoxy)methyl]-3H-purin-6-one
CAS Number:
59277-89-3 (unlabeled)
Purity:
≥96%
Molecular Weight:
229.23
Molecular Formula:
C8H7D4N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Acyclovir-d4 is a deuterium-labeled analog of acyclovir, primarily utilized in analytical research to assess the kinetics and distribution of acyclovir through advanced spectroscopic and chromatographic techniques. The incorporation of deuterium atoms (d4) into the molecule provides a stable isotope tracer that researchers can use to monitor and measure Acyclovir-d4 in complex biological matrices with high precision. It is also employed as an internal standard for mass spectrometry, enhancing the accuracy of quantitative analyses. In addition, Acyclovir-d4 aids researchers in studying the metabolic pathways of acyclovir by serving as a non-radioactive label that can be safely used in various experimental applications.


Acyclovir-d4 (CAS 59277-89-3 (unlabeled)) References

  1. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus.  |  Li, Z., et al. 1999. Antivir Chem Chemother. 10: 251-7. PMID: 10574180
  2. Antiviral drugs in wastewater and surface waters: a new pharmaceutical class of environmental relevance?  |  Prasse, C., et al. 2010. Environ Sci Technol. 44: 1728-35. PMID: 20108960
  3. Herpes zoster cervical myelitis in a young adult.  |  Lee, CC., et al. 2010. J Chin Med Assoc. 73: 605-10. PMID: 21093831
  4. Controlled ex-vivo plasma hydrolysis of valaciclovir to acyclovir demonstration using tandem mass spectrometry.  |  Goswami, D., et al. 2011. Biomed Chromatogr. 25: 1189-200. PMID: 21400550
  5. Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman: A case report and review of the literature.  |  Charnot-Katsikas, A., et al. 2016. J Clin Virol. 75: 27-32. PMID: 26745830
  6. Biotransformation of acyclovir by an enriched nitrifying culture.  |  Xu, Y., et al. 2017. Chemosphere. 170: 25-32. PMID: 27974268
  7. Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation.  |  Schimek, D., et al. 2018. Biomed Chromatogr. 32: e4194. PMID: 29349796
  8. A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of valacyclovir and its metabolite acyclovir in mouse and human plasma.  |  Shi, J., et al. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1092: 447-452. PMID: 29945109
  9. Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice.  |  Hu, Y., et al. 2018. Biochem Pharmacol. 156: 147-156. PMID: 30121252
  10. Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS.  |  Ärlemalm, A., et al. 2022. Biomed Chromatogr. 36: e5315. PMID: 34981553
  11. Prediction of Oral Drug Absorption in Rats from In Vitro Data.  |  Akiyama, Y., et al. 2023. Pharm Res. 40: 359-373. PMID: 35169960

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Acyclovir-d4, 1 mg

sc-217578
1 mg
$326.00