Molecular structure of ACPT-II, CAS Number: 195209-04-2
ACPT-II (CAS 195209-04-2)
Alternate Names:
(1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Application:
ACPT-II is a competitive mGluR (metabotropic receptor) antagonist
CAS Number:
195209-04-2
Molecular Weight:
217.18
Molecular Formula:
C8H11NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ACPT-II has been shown to act as a competitive metabotropic receptor antagonist with KB values of 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively.
ACPT-II (CAS 195209-04-2) References
- Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site. | Bessis, AS., et al. 1999. Neuropharmacology. 38: 1543-51. PMID: 10530816
- Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution. | Parmentier, ML., et al. 2000. Neuropharmacology. 39: 1119-31. PMID: 10760355
- Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. | De Colle, C., et al. 2000. Eur J Pharmacol. 394: 17-26. PMID: 10771029
- A systemic administration of NMDA induces immediate early gene pip92 in the hippocampus. | Chung, KC., et al. 2000. J Neurochem. 75: 9-17. PMID: 10854241
- Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. | Casado, M., et al. 2000. Proc Natl Acad Sci U S A. 97: 11593-7. PMID: 11016958
- Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. | Bessis, AS., et al. 2002. Proc Natl Acad Sci U S A. 99: 11097-102. PMID: 12151600
- Estimation of ligand efficacies of metabotropic glutamate receptors from conformational forces obtained from molecular dynamics simulations. | Lakkaraju, SK., et al. 2013. J Chem Inf Model. 53: 1337-49. PMID: 23688150
- Targeting mGluR group III for the treatment of neurodegenerative diseases. | Rabeh, N., et al. 2023. Biomed Pharmacother. 168: 115733. PMID: 37862967
- Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. | Acher, FC., et al. 1997. J Med Chem. 40: 3119-29. PMID: 9301676
- An Introduction to Molecular Modeling of G-Protein Coupled Receptors[J]. | Wang M, Kotra L P, Hampson D R. 2006,. Current Computer-Aided Drug Design,. 2(3):: 215-227.
Inhibitor of:
mGluR-1a, mGluR-2, and mGluR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACPT-II, 10 mg | sc-361100 | 10 mg | $179.00 | |||
ACPT-II, 50 mg | sc-361100A | 50 mg | $739.00 |