Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (117): sc-65786
- Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (117) is a rat monoclonal IgG2b provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRβ1 of Torpedo origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (117). This work is in progress.
AChRβ1Antibody (117) is a rat monoclonal IgG2b antibody that detects AChRβ1 in Torpedo species through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRβ1, also known as CHRNB, CMS1D, CMS2A, SCCMS, or CHRNB1, is a crucial component of the nicotinic acetylcholine receptor, which plays a vital role in synaptic transmission at the neuromuscular junction. This 501 amino acid protein is part of the ligand-gated ion channel family and is essential for rapid communication between nerve and muscle cells. The receptor′s structure, composed of five homologous subunits that form a transmembrane aqueous pore, allows for selective passage of ions when acetylcholine binds, facilitating muscle contraction. Proper functioning of AChRβ1 is critical, as defects in AChRβ1 can lead to congenital myasthenic syndrome slow-channel type (SCCMS), a condition characterized by muscle weakness affecting various muscle groups, including those responsible for eye movement and facial expressions. Anti-AChRβ1 antibody (117) enables researchers to explore the dynamics of this important receptor and its implications in neuromuscular disorders, enhancing understanding of synaptic transmission and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (117) | sc-65786 | 200 µg/ml | $316.00 |