Acetyl-Pepstatin CAS: 28575-34-0
MF: C31H57N5O9
MW: 643.82
An inhibitor of aspartyl protease and HIV proteinase.

Acetyl-Pepstatin (CAS 28575-34-0)

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Application: Acetyl-Pepstatin is an inhibitor of aspartyl protease and HIV proteinase
CAS Number: 28575-34-0
Molecular Weight: 643.82
Molecular Formula: C31H57N5O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Acetyl-Pepstatin is an aspartyl protease inhibitor. It has been found to effectively inhibit HIV-1 protease and HIV-2 protease. It was also found to suppress 125I-H77, a renin inhibitor, from binding to other aspartyl proteases.


References

1. Richards, A.D., et al. 1989. FEBS Lett. 247: 113-117. PMID: 2651157
2. Richards, A.D., et al. 1989. FEBS Lett. 253: 214-216. PMID: 2668032
3. Song, K., et al. 1992. Kidney Int. 42: 639-646. PMID: 1405342
4. Ullrich, B., et al. 2000. Protein Sci. 9: 2232-2245. PMID: 11152134

Physical State :
Solid
Solubility :
Soluble in 50% acetic acid.
Storage :
Store at -20° C
Boiling Point :
992.79° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
HIV1 protease: IC50 = 0.15 ug/ml
Ki Data :
HIV-1 proteinase: Ki= 20 nM at pH 4.7; HIV-2 proteinase: Ki= 5 nM at pH 4.7
pK Values :
pKa: 4.17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5481345
MDL Number :
MFCD00214071
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(C)C)[[email protected]](CC(=O)O)O)NC(=O)C[[email protected]@H]([[email protected]](CC(C)C)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](C(C)C)NC(=O)C)O

Download SDS (MSDS)

Certificate of Analysis

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