Molecular structure of Acetyl-Pepstatin, CAS Number: 28575-34-0
Acetyl-Pepstatin (CAS 28575-34-0)
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Application:
Acetyl-Pepstatin is an inhibitor of aspartyl protease and HIV proteinase
CAS Number:
28575-34-0
Molecular Weight:
643.82
Molecular Formula:
C31H57N5O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Acetyl-Pepstatin is an aspartyl protease inhibitor. It has been found to effectively inhibit HIV-1 proteinase and HIV-2 proteinase. It was also found to suppress 125I-H77, a renin inhibitor, from binding to other aspartyl proteases.
Acetyl-Pepstatin (CAS 28575-34-0) References
- Trp42 rotamers report reduced flexibility when the inhibitor acetyl-pepstatin is bound to HIV-1 protease. | Ullrich, B., et al. 2000. Protein Sci. 9: 2232-45. PMID: 11152134
- A new method to localize active renin in tissues by autoradiography: application to dog kidney. | Song, K., et al. 1992. Kidney Int. 42: 639-46. PMID: 1405342
- Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. | Matúz, K., et al. 2012. FEBS J. 279: 3276-86. PMID: 22804908
- Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. | Richards, AD., et al. 1989. FEBS Lett. 247: 113-7. PMID: 2651157
- Inhibition of the aspartic proteinase from HIV-2. | Richards, AD., et al. 1989. FEBS Lett. 253: 214-6. PMID: 2668032
- Biochemical Characterization of Human Retroviral-Like Aspartic Protease 1 (ASPRV1). | Golda, M., et al. 2020. Biomolecules. 10: PMID: 32640672
- Development and validation of LC-MS/MS method for quantification of protease inhibitor Pepstatin A to monitor its robust clearance in vaccine downstream process. | Jiang, T., et al. 2023. J Chromatogr B Analyt Technol Biomed Life Sci. 1215: 123589. PMID: 36592589
- Binding of Streptomyces pepsin inhibitor (acetyl-pepstatin) with chymosin (Rennin). | Nakatani, H., et al. 1980. Biochim Biophys Acta. 614: 144-50. PMID: 6772226
- Solution structure of the HIV protease inhibitor acetyl-pepstatin as determined by NMR and molecular modeling. | van Boulanger, Y., et al. 1997. J Biomol Struct Dyn. 14: 421-8. PMID: 9172642
- Bacterial aspartic proteinases. | Hill, J. and Phylip, LH. 1997. FEBS Lett. 409: 357-60. PMID: 9224689
Inhibitor of:
HIV-1 Protease, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetyl-Pepstatin, 1 mg | sc-203802 | 1 mg | $177.00 |