ABC1 Antibody (A00121.01): sc-81779

ABC1 Antibody (A00121.01) is a mouse monoclonal IgG1 antibody that detects ABC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). ABC1, or ATP-binding cassette transporter 1, plays a crucial role in lipid metabolism by facilitating the efflux of cholesterol and phospholipids from cells, which is essential for maintaining cellular homeostasis and preventing the accumulation of lipids that can lead to atherosclerosis. ABC1 is predominantly located in the plasma membrane of various cell types, including macrophages, where ABC1 is involved in the transport of lipids to high-density lipoproteins for excretion from the body. This function is particularly important in the context of cardiovascular health, as impaired ABC1 activity is associated with conditions such as Tangier disease, characterized by low levels of high-density lipoprotein and increased risk of cardiovascular disease. Anti-ABC1 antibody (A00121.01) can be utilized in various experimental settings to study the expression and function of this vital protein, providing insights into its role in lipid metabolism and related diseases.

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ABC1 Antibody (A00121.01) References:

1. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1.  |  Rust, S., et al. 1999. Nat Genet. 22: 352-5. PMID: 10431238
2. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.  |  McNeish, J., et al. 2000. Proc Natl Acad Sci U S A. 97: 4245-50. PMID: 10760292
3. Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites.  |  Bungert, S., et al. 2001. J Biol Chem. 276: 23539-46. PMID: 11320094
4. ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.  |  Marty, V., et al. 2005. Glia. 49: 511-9. PMID: 15578659
5. ATP-binding cassette transporter 1 and transglutaminase 2 act on the same genetic pathway in the apoptotic cell clearance.  |  Iadevaia, V., et al. 2006. Cell Death Differ. 13: 1998-2001. PMID: 16691213
6. Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes.  |  Sigruener, A., et al. 2007. Horm Metab Res. 39: 781-9. PMID: 17992631
7. Cytokine signaling modulates blood-brain barrier function.  |  Pan, W., et al. 2011. Curr Pharm Des. 17: 3729-40. PMID: 21834767
8. Influence of ATP-binding cassette transporter 1 R219K and M883I polymorphisms on development of atherosclerosis: a meta-analysis of 58 studies.  |  Yin, YW., et al. 2014. PLoS One. 9: e86480. PMID: 24466114
9. Glial cholesterol redistribution in hypoxic injury in vitro influences oligodendrocyte maturation and myelination.  |  Shrivastava, V., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167476. PMID: 39181517
10. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.  |  Luciani, MF. and Chimini, G. 1996. EMBO J. 15: 226-35. PMID: 8617198

The preferred ABC1 antibody is ABC1 Antibody (AB.H10): sc-58219.