A 61603 HYDROBROMIDE CAS: 107756-30-9
MF: C14H19N3O3S HBr
MW: 390.29
A potent α-adrenoceptor agonist.

A 61603 HYDROBROMIDE (CAS 107756-30-9)

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Application: A 61603 HYDROBROMIDE is a potent α-adrenoceptor agonist
CAS Number: 107756-30-9
Molecular Weight: 390.29
Molecular Formula: C14H19N3O3S HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

A 61603 HYDROBROMIDE is a potent alpha1A-AR (α-adrenoceptor) agonist, at least 35-fold more potent at α1A-ar than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro.


References

Knepper et al (1995) A-61603, a potent a1-adrenergic receptor agonist, selective for the a1A receptor subtype. J.Pharmacol.Exp.Ther. 274 97. Meyer et al (1996) Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective a1A receptor agonist. J.Med.Chem. 39 4116. Luo et al (2007) Receptor subtype involved in a1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 28 968.

Physical State :
Solid
Solubility :
Soluble in water (50 mM).
Storage :
Desiccate at 4° C
Boiling Point :
584.4° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9865178
MDL Number :
MFCD02262217
SMILES :
CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O.Br

Download SDS (MSDS)

Certificate of Analysis

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