A 61603 HYDROBROMIDE (CAS 107756-30-9)
Available in US only.
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A 61603 HYDROBROMIDE is a potent alpha1A-AR (alpha-adrenoceptor) agonist, at least 35-fold more potent at alpha1A-ar than at alpha1B or alpha1D sites. It induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro. Additionally, it is a derivative of the naturally occurring amino acid gamma-aminobutyric acid (GABA) and is used as a specific agonist of the GABA receptor. A 61603 Hydrobromide may act to modulate the activity of various enzymes and proteins, such as cyclooxygenase-2, phospholipase C, and nitric oxide synthase. It has also been shown to modulate the activity of various ion channels, such as the A 61603 Hydrobromide receptor, the glutamate receptor, and the NMDA receptor. Studies have found anxiolytic, anticonvulsant, and antidepressant, anti-inflammatory, and anti-apoptotic effects of A 61603 Hydrobromide. Furthermore, it can modulate the release of neurotransmitters such as dopamine, serotonin, and norepinephrine.
A 61603 HYDROBROMIDE (CAS 107756-30-9) References
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- α(1D)-Adrenoceptor regulates the vasopressor action of α(1A)-adrenoceptor in mesenteric vascular bed of α(1D)-adrenoceptor knockout mice. | Martínez-Salas, SG., et al. 2011. Auton Autacoid Pharmacol. 31: 64-71. PMID: 21951586
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- Adrenoceptor function and expression in bladder urothelium and lamina propria. | Moro, C., et al. 2013. Urology. 81: 211.e1-7. PMID: 23200975
- α1L-adrenoceptors mediate contraction of human erectile tissue. | Davis, BJ., et al. 2018. J Pharmacol Sci. 137: 366-371. PMID: 30139713
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 61603 HYDROBROMIDE, 10 mg | sc-203789 | 10 mg | $398.00 | |||
| US: Only available in the US | ||||||
A 61603 HYDROBROMIDE, 50 mg | sc-203789A | 50 mg | $1607.00 | |||
| US: Only available in the US | ||||||