A 286982 (CAS 280749-17-9)
See product citations (2)
QUICK LINKS
A 286982 is a potent inhibitor known for its ability to block the interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1). It effectively inhibits this integrin-ligand interaction with a measured IC50 value of 35 nM. Furthermore, A 286982 demonstrates its inhibitory properties by significantly reducing the adhesion of JY-8 cells to ICAM-1-coated microtiter plates, with an IC50 value of 44 nM. Its specific role lies in obstructing the interaction between LFA-1 and ICAM-1, making A 286982 a promising inhibitor with potential applications in various contexts related to leukocyte function-associated antigen-1 and intercellular adhesion molecule-1.
A 286982 (CAS 280749-17-9) References
- Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. | Liu, G., et al. 2000. J Med Chem. 43: 4025-40. PMID: 11052808
- Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. | Yusuf-Makagiansar, H., et al. 2002. Med Res Rev. 22: 146-67. PMID: 11857637
- Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. | Keating, SM., et al. 2006. Protein Sci. 15: 290-303. PMID: 16384997
- Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor. | Swaim, CD., et al. 2017. Mol Cell. 68: 581-590.e5. PMID: 29100055
- Approaches for investigating the extracellular signaling function of ISG15. | Swaim, CD., et al. 2019. Methods Enzymol. 618: 211-227. PMID: 30850053
- Cinnamamide: An insight into the pharmacological advances and structure-activity relationships. | Gaikwad, N., et al. 2019. Eur J Med Chem. 181: 111561. PMID: 31376564
- Proteomic and phospholipidomic characterization of extracellular vesicles inducing tumor microenvironment in Epstein-Barr virus-associated lymphomas. | Ito, M., et al. 2021. FASEB J. 35: e21505. PMID: 33723887
- Depletion of Ift88 in thymic epithelial cells affects thymic synapse and T-cell differentiation in aged mice. | Kutomi, O., et al. 2022. Anat Sci Int. 97: 409-422. PMID: 35435578
- Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. | de Waal Malefyt, R., et al. 1993. J Immunol. 150: 4754-65. PMID: 7684412
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 286982, 10 mg | sc-362705 | 10 mg | $217.00 | |||
A 286982, 50 mg | sc-362705A | 50 mg | $916.00 |