A 286982 CAS: 280749-17-9
MF: C24H27N3O4S
MW: 453.55
A potent LFA-1/ICAM-1 interaction inhibitor.

A 286982 (CAS 280749-17-9)

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Alternate Names: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Application: A 286982 is a potent LFA-1/ICAM-1 interaction inhibitor
CAS Number: 280749-17-9
Molecular Weight: 453.55
Molecular Formula: C24H27N3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 = 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion, respectively).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage :
Store at -20° C
Melting Point :
265.50° C (Predicted)
Boiling Point :
~648.8° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
LFA-1-mediated cell adhesion assays: IC50 = 35 nM; LFA-1/ICAM-1 binding: IC50 = 44 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9846729
MDL Number :
MFCD19690958
SMILES :
CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)/C=C/C(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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A 286982 (CAS 280749-17-9)  Product Citations

See how others have used A 286982 (CAS 280749-17-9). Click on the entry to view the PubMed entry .

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PMID: # 29568062  Sci Rep. 8: 5067.

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