8(R)-HETE (CAS 105500-09-2)

8(R)-HETE, bearing the CAS number 105500-09-2, represents a specific enantiomer of 8-hydroxyeicosatetraenoic acid, a metabolite derived from the lipoxygenase-mediated oxidation of arachidonic acid. This particular isomer is characterized by the positional and stereo-specific placement of a hydroxyl group on the eighth carbon in the R configuration. As an active lipid mediator, 8(R)-HETE plays a crucial role in the regulation of various intracellular signaling pathways that influence cellular functions such as migration, adhesion, and the modulation of inflammatory mediator synthesis. In research settings, 8(R)-HETE is valued for its utility in elucidating the mechanisms through which oxygenated derivatives of essential fatty acids influence cell signaling. Its interaction with specific receptors and signaling proteins allows researchers to probe the dynamics of lipid signaling in cellular communication and response mechanisms. Studies involving 8(R)-HETE have provided significant insights into the complex roles of lipid mediators in the regulation of cellular environments, particularly in understanding how cells react to and manage oxidative stress and other signaling disruptions. This research contributes broadly to the field of cell biology, offering deeper understanding of the nuanced regulatory roles that such lipid mediators play in maintaining cellular homeostasis.