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8-Quinolinethiol hydrochloride (CAS 34006-16-1)

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Alternate Names:
8-Mercaptoquinoline hydrochloride
Application:
8-Quinolinethiol hydrochloride is also known as Thiooxine hydrochloride
CAS Number:
34006-16-1
Purity:
≥95%
Molecular Weight:
197.68
Molecular Formula:
C9H7NS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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8-Quinolinethiol hydrochloride, a heterocyclic building block. 8-Quinolinethiol hydrochloride is a quinoline derivative, which is an aromatic compound known for its six-membered ring structure. Extensive research has been conducted to explore the potential applications of 8-Quinolinethiol hydrochloride in understanding various biochemical and physiological processes, including gene expression regulation, cellular metabolism modulation, and signal transduction pathway regulation. Although the precise mechanism of action remains incompletely understood, it is hypothesized that 8-Quinolinethiol hydrochloride acts as an inhibitor of cytochrome P450 enzymes. This inhibitory effect is postulated to arise from the formation of a covalent bond between the 8-thiol group of 8-Quinolinethiol hydrochloride and the heme group present in cytochrome P450 enzymes.


8-Quinolinethiol hydrochloride (CAS 34006-16-1) References

  1. Synthesis and mechanistic studies of quinolin-chlorobenzothioate derivatives with proteasome inhibitory activity in pancreatic cancer cell lines.  |  Hu, S., et al. 2018. Eur J Med Chem. 158: 884-895. PMID: 30253345
  2. The Fluorometric Determination of Gallium in Aluminum Metal with 8-Quinolinethiol  |  Watanabe, K., & Kawagaki, K. O. Z. O. 1975. Bulletin of the Chemical Society of Japan. 48(6): 1812-1815.
  3. Formation of the TcN multiple bond from the reaction of ammonium pertechnetate with S-methyl dithiocarbazate and its application to the preparation of technetium-99m radiopharmaceuticals  |  Duatti, A., Marchi, A., & Pasqualini, R. 1990. Journal of the Chemical Society, Dalton Transactions. (12): 3729-3733.
  4. A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the Tc N multiple bond  |  Pasqualini, R., Comazzi, V., Bellande, E., Duatti, A., & Marchi, A. 1992. International journal of radiation applications and instrumentation. Part A. Applied radiation and isotopes. 43(11): 1329-1333.
  5. Thiol and disulfide addition to the pendant vinylbenzene groups of poly(divinylbenzene-co-ethylvinylbenzene), including Amberlite XAD-4  |  KL Hubbard, JA Finch, GD Darling. 1999. Reactive and Functional Polymers. 40(1): 61-90.
  6. Synthesis and coordination chemistry of tetradentate ligands containing two bidentate thioquinoline units: mononuclear complexes with Cu (I) and Cu (II), and a coordination polymer with Cu (I)  |  Tavacoli, S., Miller, T. A., Paul, R. L., Jeffery, J. C., & Ward, M. D. 2003. Polyhedron. 22(4): 507-514.
  7. Novel synergism by complex ligands in solvent extraction of rare earth metals (III) with β-diketones  |  Imura, H., Ebisawa, M., Kato, M., & Ohashi, K. 2006. Journal of alloys and compounds. 408: 952-957.
  8. Synthesis, spectroscopic characterization, X-ray structure and DFT calculations of [ReOCl2(8-Sqn)(OPPh3)]  |  Machura, B., Świtlicka, A., Wolff, M., & Kusz, J. 2009. Structural Chemistry. 20: 911-918.
  9. Synthesis and photophysical properties of isocyano Ruthenium(II) quinoline-8-thiolate complexes with visible-light and near-infrared emission  |  Leung, C. F., & Ko, C. C. 2016. Journal of Organometallic Chemistry. 804: 101-107.
  10. Ruthenium-8-quinolinethiolate-phenylterpyridine versus ruthenium-bipyridine-phenyl-terpyridine complexes as homogeneous water and high temperature stable hydrogenation catalysts for biomass-derived substrates  |  Sullivan, R. J., Kim, J., Hoyt, C., Silks III, L. A. P., & Schlaf, M. 2016. Polyhedron. 108: 104-114.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Quinolinethiol hydrochloride, 1 g

sc-391289
1 g
$286.00