Molecular structure of 8-Nitroguanosine, CAS Number: 337536-53-5
8-Nitroguanosine (CAS 337536-53-5)
Application:
8-Nitroguanosine is a redox-active nucleic acid derivative used as biomarker of exposure to reactive nitrogen species
CAS Number:
337536-53-5
Molecular Weight:
328.24
Molecular Formula:
C10H12N6O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-Nitroguanosine is a highly reactive redox-active nucleic acid derivative that is is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis. 8-Nitroguanosine formed in vivo may function as a potent redox cofactor that intensifies oxyradical generation by various NADPH/reductase-like enzymes and thus participates in diverse physiological and pathological events.
8-Nitroguanosine (CAS 337536-53-5) References
- Formation of 8-nitroguanosine in cellular RNA as a biomarker of exposure to reactive nitrogen species. | Masuda, M., et al. 2002. Chem Biol Interact. 139: 187-97. PMID: 11823006
- Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative. | Sawa, T., et al. 2003. Biochem Biophys Res Commun. 311: 300-6. PMID: 14592413
- Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis. | Akuta, T., et al. 2006. Nitric Oxide. 14: 101-8. PMID: 16309933
- Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells. | Kaneko, K., et al. 2008. Cancer Lett. 262: 239-47. PMID: 18248787
- Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: involvement of estrogen receptor-dependent or -independent pathways. | Yoshitake, J., et al. 2008. Nitric Oxide. 18: 223-8. PMID: 18252206
- 1α,25-Dihydroxyvitamin D3 reduces several types of UV-induced DNA damage and contributes to photoprotection. | Song, EJ., et al. 2013. J Steroid Biochem Mol Biol. 136: 131-8. PMID: 23165145
- Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex. | Fuchi, Y. and Sasaki, S. 2014. Org Lett. 16: 1760-3. PMID: 24606012
- New NitroG-Grasp Molecules with Enhanced Capture Reactivity for 8-Nitroguanosine in the Aqueous Media. | Fuchi, Y. and Sasaki, S. 2015. Chem Pharm Bull (Tokyo). 63: 913-9. PMID: 26521855
- Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations. | Barbosa, TM., et al. 2016. Nucleosides Nucleotides Nucleic Acids. 35: 53-63. PMID: 26810486
- Biochemical pathways of 8-aminoguanine production in Sprague-Dawley and Dahl salt-sensitive rats. | Jackson, EK., et al. 2022. Biochem Pharmacol. 201: 115076. PMID: 35551915
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Nitroguanosine, 10 mg | sc-478514 | 10 mg | $750.00 |