Date published: 2025-12-8

1-800-457-3801

SCBT Portrait Logo
Seach Input

8-Bromoadenine (CAS 6974-78-3)

0.0(0)
Write a reviewAsk a question

Alternate Names:
6-Amino-8-bromopurine
CAS Number:
6974-78-3
Molecular Weight:
214.02
Molecular Formula:
C5H4BrN5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

8-Bromoadenine, a synthetic compound of immense scientific significance, has found extensive applications in diverse research endeavors. Serving as a nucleotide analogue and purine base, it plays a pivotal role as a fundamental constituent for an array of biochemical and physiological investigations. The distinct structure and properties of 8-Bromoadenine have prompted thorough examinations of its chemical and biochemical characteristics. The versatile utility of 8-Bromoadenine spans across various scientific research domains. It assumes a role in studying pivotal processes such as DNA replication and repair and gene expression. By employing 8-Bromoadenine, researchers gain valuable insights into the impact of different nucleotides on DNA replication and repair mechanisms. In essence, 8-Bromoadenine holds a prominent position in scientific research, offering indispensable contributions to investigations involving DNA replication, repair, gene expression and protein structure. Its distinct role as a nucleotide analogue and purine base has propelled its widespread use and garnered substantial attention from the scientific community.


8-Bromoadenine (CAS 6974-78-3) References

  1. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.  |  Jin, G., et al. 2006. Bioorg Med Chem Lett. 16: 4559-63. PMID: 16784848
  2. Fundamental mechanisms of DNA radiosensitization: damage induced by low-energy electrons in brominated oligonucleotide trimers.  |  Park, Y., et al. 2012. J Phys Chem B. 116: 9676-82. PMID: 22812492
  3. Enzymatic properties of 8-bromoadenine nucleotides.  |  Lascu, I., et al. 1979. Biochemistry. 18: 4818-26. PMID: 228699
  4. Electron-induced degradation of 8-bromo-2'-deoxyadenosine 3',5'-diphosphate, a DNA radiosensitizing nucleotide.  |  Chomicz, L., et al. 2013. J Phys Chem B. 117: 8681-8. PMID: 23802987
  5. Real-time monitoring of plasmon induced dissociative electron transfer to the potential DNA radiosensitizer 8-bromoadenine.  |  Schürmann, R. and Bald, I. 2017. Nanoscale. 9: 1951-1955. PMID: 28098304
  6. Stability of the Parent Anion of the Potential Radiosensitizer 8-Bromoadenine Formed by Low-Energy (
  7. Resonant Formation of Strand Breaks in Sensitized Oligonucleotides Induced by Low-Energy Electrons (0.5-9 eV).  |  Schürmann, R., et al. 2017. Angew Chem Int Ed Engl. 56: 10952-10955. PMID: 28670830
  8. Formation of 8-S-L-Cysteinyladenosine from 8-Bromoadenosine and Cysteine.  |  Suzuki, T., et al. 2018. Chem Pharm Bull (Tokyo). 66: 184-187. PMID: 29386470
  9. Vacuum-UV induced DNA strand breaks - influence of the radiosensitizers 5-bromouracil and 8-bromoadenine.  |  Vogel, S., et al. 2019. Phys Chem Chem Phys. 21: 1972-1979. PMID: 30633275
  10. Halogen Bonds in Protein Nucleic Acid Recognition.  |  Frontera, A. and Bauzá, A. 2020. J Chem Theory Comput. 16: 4744-4752. PMID: 32579358
  11. Plasmonic Hot Electron-Mediated Hydrodehalogenation Kinetics on Nanostructured Ag Electrodes.  |  Liu, J., et al. 2020. J Am Chem Soc. 142: 17489-17498. PMID: 32941020
  12. Directed glycosylation of 8-bromoadenine. Synthesis and reactions of 8-substituted 3-glycosyladenine derivatives.  |  Tindall, CG., et al. 1972. J Org Chem. 37: 3985-9. PMID: 4643015
  13. Formation of 3-(2'-deoxyribofuranosyl) and 9-(2'-deoxyribofuranosyl) nucleosides of 8-substituted purines by nucleoside deoxyribosyltransferase.  |  Huang, MC., et al. 1983. Arch Biochem Biophys. 222: 133-44. PMID: 6838216
  14. [Radiosensitizing action of 8-bromoadenine on hematopoietic stem cells in mouse bone marrow].  |  Volchkov, VA., et al. 1982. Radiobiologiia. 22: 117-9. PMID: 7063645
  15. The solid-phase synthesis of 2'-5'-linked oligoriboadenylates containing 8-bromoadenine.  |  Lesiak, KB., et al. 1997. Appl Biochem Biotechnol. 67: 33-44. PMID: 9382489

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Bromoadenine, 100 mg

sc-280578
100 mg
$102.00