8-Amino Adenosine (CAS 3868-33-5)
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8-Amino Adenosine (8-AA) is a naturally occurring compound that holds significant importance within the human body as a pivotal intermediate in the synthesis of adenosine, a nucleoside. Moreover, it assumes a central role in essential biological processes, including DNA replication, RNA transcription, and protein translation. Researchers have harnessed the potential of 8-Amino Adenosine as useful for investigating enzyme kinetics, given its capacity to serve as a substrate for numerous enzymes. Furthermore, its application extends to the exploration of gene regulation, where it exhibits the ability to impede transcription as an inhibitor. Within the realm of cell signaling, 8-Amino Adenosine serves as a versatile agent, acting as both an agonist and antagonist for specific receptors. Notably, it functions as an allosteric modulator, capable of binding to the active site of an enzyme and inducing conformational changes that profoundly impact the enzyme′s activity.
8-Amino Adenosine (CAS 3868-33-5) References
- 8-amino-adenosine is a potential therapeutic agent for multiple myeloma. | Krett, NL., et al. 2004. Mol Cancer Ther. 3: 1411-20. PMID: 15542780
- 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma. | Ghias, K., et al. 2005. Mol Cancer Ther. 4: 569-77. PMID: 15827330
- 8-Amino-adenosine inhibits multiple mechanisms of transcription. | Frey, JA. and Gandhi, V. 2010. Mol Cancer Ther. 9: 236-45. PMID: 20053765
- Multifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells. | Pillai, RN., et al. 2012. Leuk Lymphoma. 53: 2024-32. PMID: 22448923
- 8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers. | Polotskaia, A., et al. 2012. Mol Cancer Ther. 11: 2495-504. PMID: 22973058
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Amino Adenosine, 25 mg | sc-221119 | 25 mg | $166.00 |