Date published: 2025-10-17

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6-Hydroxycoumarin (CAS 6093-68-1)

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CAS Number:
6093-68-1
Purity:
≥99%
Molecular Weight:
162.14
Molecular Formula:
C9H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Hydroxycoumarin is a compound that functions as a fluorescent probe in biochemical and cellular assays. It is used to detect and measure the presence of metal ions, particularly iron, in biological samples. The compound chelates with metal ions, leading to a change in its fluorescence properties, allowing for the quantification of metal ion concentrations. 6-Hydroxycoumarin also acts as a photosensitizer in photodynamic, where it generates reactive oxygen species upon exposure to light, leading to cell death. It serves as a precursor in the synthesis of various agrochemicals due to its ability to undergo chemical transformations to yield diverse chemical structures. In a development setting, 6-Hydroxycoumarin is utilized for its role in fluorescence-based assays and as a starting material for the synthesis of biologically active compounds. Its mechanism of action involves interactions with metal ions and light-induced generation of reactive oxygen species, making it versatile for various experimental applications.


6-Hydroxycoumarin (CAS 6093-68-1) References

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  2. Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells.  |  Adfa, M., et al. 2012. Biol Pharm Bull. 35: 963-6. PMID: 22687539
  3. Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.  |  Shakeel-u-Rehman, ., et al. 2014. Bioorg Med Chem Lett. 24: 4243-6. PMID: 25088398
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  5. Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cells.  |  de Araujo Leite, JC., et al. 2015. J Photochem Photobiol B. 146: 44-51. PMID: 25795999
  6. Origin of Remarkably Different Acidity of Hydroxycoumarins-Joint Experimental and Theoretical Studies.  |  Nowak, PM., et al. 2017. J Phys Chem B. 121: 4554-4561. PMID: 28406631
  7. Structural, vibrational and electronic spectroscopic study of 6-hydroxycoumarin using experimental and theoretical methods.  |  Vijay, D., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 229: 117930. PMID: 31931406
  8. 3-Aminophenyl Boronic Acid Functionalized Quantum-Dot-Based Ratiometric Fluorescence Sensor for the Highly Sensitive Detection of Tyrosinase Activity.  |  Wang, M., et al. 2020. ACS Sens. 5: 1634-1640. PMID: 32486639
  9. The First Step of Biodegradation of 7-Hydroxycoumarin in Pseudomonas mandelii 7HK4 Depends on an Alcohol Dehydrogenase-Type Enzyme.  |  Krikštaponis, A., et al. 2021. Int J Mol Sci. 22: PMID: 33557119
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  11. Quantifying OH radical generation in hydrodynamic cavitation via coumarin dosimetry: Influence of operating parameters and cavitation devices.  |  De-Nasri, SJ., et al. 2022. Ultrason Sonochem. 90: 106207. PMID: 36335794
  12. Phytochemistry and Pharmacology of Medicinal Plants Used by the Tenggerese Society in Java Island of Indonesia.  |  Nugraha, AS., et al. 2022. Molecules. 27: PMID: 36364351
  13. Enhanced Monitoring of Photocatalytic Reactive Oxygen Species: Using Electrochemistry for Rapid Sensing of Hydroxyl Radicals Formed during the Degradation of Coumarin.  |  McCormick, WJ., et al. 2023. J Phys Chem A. 127: 5039-5047. PMID: 37257064

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Hydroxycoumarin, 1 g

sc-233599
1 g
$37.00