6-Azauridine-5′-monophosphate (CAS 2018-19-1)

The human exosome complex, which includes EXOSC (exosome component) proteins, is a multi-protein complex with 3′-5′ exoribonuclease activity. This complex is crucial for the processing, degradation, and quality control of a wide variety of RNA species, including mRNA, rRNA, and tRNA. The EXOSC proteins within the complex serve as structural and functional constituents that facilitate the catalytic activity of the exosome. Signaling to and from the exosome complex often involves interactions with other cellular machinery, such as spliceosomes and ribosomes, to coordinate RNA metabolism. Overall, the EXOsc-regulated exosome complex serves as a central hub for RNA processing and degradation, ensuring the integrity and functionality of cellular RNA pools. EXOSC (exosome component) inhibitors comprise a specialized class of chemical compounds that target the exosome complex, a cellular structure involved in 3′-5′ exoribonuclease activities that participate in RNA processing and degradation. EXOSC inhibitors can operate through a range of mechanisms to affect these processes. Some may directly inhibit the enzymatic activities associated with the EXOSC components, while others might affect the assembly or stability of the exosome complex itself. Additionally, certain EXOSC inhibitors may act indirectly, targeting upstream or downstream elements that modulate the exosome′s actions, thereby affecting RNA metabolism.