Molecular structure of 6-Amidino-2-naphthol Hydrochloride, CAS Number: 66217-10-5
6-Amidino-2-naphthol Hydrochloride (CAS 66217-10-5)
Application:
6-Amidino-2-naphthol Hydrochloride is a metabolite of Nafamostat Mesylate (NM)
CAS Number:
66217-10-5
Molecular Weight:
222.67
Molecular Formula:
C11H11ClN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Amidino-2-naphthol Hydrochloride is the hydrochloride salt preparation of 6-Amidino-2-naphthol, a major metabolite of the serine-protease inhibitor Nafamostat mesylate (sc-201307). This metabolite has been described in studies probing the inhibitory action of Nafamostat and is described to be a catalytically inert species, demonstrating no effect upon prostasin secretion in M-1 cells and in rats which Nafamostat was shown to inhibit.
6-Amidino-2-naphthol Hydrochloride (CAS 66217-10-5) References
- Inhibition of prostasin secretion by serine protease inhibitors in the kidney. | Iwashita, K., et al. 2003. J Am Soc Nephrol. 14: 11-6. PMID: 12506133
- Stability of nafamostat in intravenous infusion solutions, human whole blood and extracted plasma: implications for clinical effectiveness studies. | Hernández-Mitre, MP., et al. 2023. Bioanalysis. 15: 673-681. PMID: 37272603
- Mechanisms of the hyperkalaemia caused by nafamostat mesilate: effects of its two metabolites on Na+ and K+ transport properties in the rabbit cortical collecting duct. | Muto, S., et al. 1994. Br J Pharmacol. 111: 173-8. PMID: 8012693
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Amidino-2-naphthol Hydrochloride, 250 mg | sc-207089 | 250 mg | $349.00 |