6(5H)-Phenanthridinone (CAS 1015-89-0)
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6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavalin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which suggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with the DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process.
6(5H)-Phenanthridinone (CAS 1015-89-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6(5H)-Phenanthridinone, 200 mg | sc-200124 | 200 mg | $20.00 |