Molecular structure of 5(S),6(R)-7-trihydroxymethyl Heptanoate, CAS Number: 78606-80-1
5(S),6(R)-7-trihydroxymethyl Heptanoate (CAS 78606-80-1)
Alternate Names:
5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
Application:
5(S),6(R)-7-trihydroxymethyl Heptanoate is a potent lipoxin A4 agonist
CAS Number:
78606-80-1
Molecular Weight:
192.2
Molecular Formula:
C8H16O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid by an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP)(1). 5(S),6(R)-7-trihydroxymethyl heptanoate is a C-7 truncated analog of LXA4 that is equiactive as LXA4 in inhibition of LTB4-induced PMN chemotaxis with an IC50 of 5nM(1).
5(S),6(R)-7-trihydroxymethyl Heptanoate (CAS 78606-80-1) References
1 Lee, T.H., Lympany, P., Crea, A.E.G., et al. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships. Biochem Biophys Res Commun 180(3) 1416-1421 (1991).Activator of:
FPR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5(S),6(R)-7-trihydroxymethyl Heptanoate, 1 mg | sc-221076 | 1 mg | $64.00 | |||
5(S),6(R)-7-trihydroxymethyl Heptanoate, 5 mg | sc-221076A | 5 mg | $188.00 |