5-Hydroxy Desloratadine (CAS 117811-12-8)
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5-Hydroxy Desloratadine is primarily recognized for its role as an active metabolite in research studies focused on allergic response and histamine activity modulation. Within laboratory applications, it is utilized to explore the pathways of histamine receptor antagonism, particularly targeting the H1-receptor subtype, which plays a critical part in immune response mechanisms. Scientists often employ this compound in molecular biology experiments to better understand the biochemical cascades involved in histamine-related signaling and to delineate its influence on gene expression related to inflammation and allergy. Additionally, 5-Hydroxy Desloratadine serves as useful in metabolic studies, aiding researchers in mapping out metabolic profiles and understanding the compound′s transformation within biological systems.
5-Hydroxy Desloratadine (CAS 117811-12-8) References
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- Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL. | Shen, JX., et al. 2006. J Pharm Biomed Anal. 40: 689-706. PMID: 16095862
- Metabolism of loratadine and further characterization of its in vitro metabolites. | Ghosal, A., et al. 2009. Drug Metab Lett. 3: 162-70. PMID: 19702548
- A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement. | Kazmi, F., et al. 2015. Drug Metab Dispos. 43: 523-33. PMID: 25595597
- Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. | Aratyn-Schaus, Y. and Ramanathan, R. 2016. Bioanalysis. 8: 1645-62. PMID: 27460981
- Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. | Uehara, S., et al. 2020. Xenobiotica. 50: 733-740. PMID: 31690163
- Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver. | Kato, S., et al. 2020. Drug Metab Dispos. 48: 934-943. PMID: 32665417
- Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method. | Zhang, Y., et al. 2020. Drug Res (Stuttg). 70: 528-540. PMID: 32877950
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Hydroxy Desloratadine, 1 mg | sc-210328 | 1 mg | $400.00 |