Molecular structure of 5-Chlorouridine, CAS Number: 2880-89-9
5-Chlorouridine (CAS 2880-89-9)
Alternate Names:
5-chloro-1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Application:
5-Chlorouridine is a potential biomarker
CAS Number:
2880-89-9
Molecular Weight:
278.65
Molecular Formula:
C9H11ClN2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Chlorouridine is a potential biomarker for analysis of chlorine stressed RNA. 5-Chlorouridine is a synthetic derivative of uridine, a nucleoside that occurs naturally in all living organisms. This compound serves as useful in the exploration of gene expression, nucleic acid metabolism, and drug metabolism. Researchers have utilized 5-Chlorouridine to investigate the activity of enzymes responsible for converting cytosine derivatives to uracil derivatives in various biological systems, including cells, tissues, and organisms. Additionally, 5-Chlorouridine has been used to study the effects of chlorine stress on RNA.
5-Chlorouridine (CAS 2880-89-9) References
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- The XNA world: progress towards replication and evolution of synthetic genetic polymers. | Pinheiro, VB. and Holliger, P. 2012. Curr Opin Chem Biol. 16: 245-52. PMID: 22704981
- Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs. | Patra, A., et al. 2013. Nucleic Acids Res. 41: 2689-97. PMID: 23275540
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- The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair. | Eremeeva, E., et al. 2016. Org Biomol Chem. 15: 168-176. PMID: 27918055
- Probing the Backbone Topology of DNA: Synthesis and Properties of 7',5'-Bicyclo-DNA. | Evéquoz, D. and Leumann, CJ. 2017. Chemistry. 23: 7953-7968. PMID: 28262999
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- Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3. | Sherstyuk, YV., et al. 2019. Int J Mol Sci. 21: PMID: 31892271
- Electron spin resonance of an irradiated single crystal of 5-chlorouridine. | Reiss, KW. and Gordy, W. 1971. Proc Natl Acad Sci U S A. 68: 2008-10. PMID: 4332244
- Base pairing in 5-chlorouridine. | Coulter, CL. and Hawkinson, SW. 1969. Proc Natl Acad Sci U S A. 63: 1359-64. PMID: 5260938
- Radiation damage in solid 5-halouracils: free radicals in single crystals of 5-fluorouracil. | Neumüller, W. and Hüttermann, J. 1980. Int J Radiat Biol Relat Stud Phys Chem Med. 37: 49-60. PMID: 6245039
- Environmental pollutant 5-chlorouracil is incorporated in mouse liver and testes DNA. | Pal, BC., et al. 1981. Mutat Res. 91: 395-401. PMID: 7266579
- Quantification of 5-fluorouridine in human urine by capillary gas-liquid chromatography with a nitrogen-selective detector. | De Leenheer, AP. and Gelijkens, CF. 1978. J Chromatogr Sci. 16: 552-5. PMID: 730817
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Chlorouridine, 1 g | sc-221022 | 1 g | $312.00 |