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5-Carboxy-2-thiouracil (CAS 23945-50-8)

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Alternate Names:
2-Thiouracil-5-carboxylic acid; 5-Carboxy-4-hydroxy-2-thiopyrimidine
Application:
5-Carboxy-2-thiouracil is a possible anti-tumor agent when part of a metal complex
CAS Number:
23945-50-8
Purity:
≥98%
Molecular Weight:
172.16
Molecular Formula:
C5H4N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Carboxy-2-thiouracil is a chemical compound that has garnered significant attention in scientific research due to its diverse range of applications and unique chemical properties. This compound has been particularly studied for its potential as a precursor in the synthesis of various pharmaceuticals and organic compounds. Its mechanism of action involves serving as a key intermediate in the synthesis of thiazole derivatives, which are important building blocks in medicinal chemistry and drug discovery. Additionally, 5-carboxy-2-thiouracil has been investigated for its role in organic synthesis reactions, including its use as a catalyst or reagent in various chemical transformations. Furthermore, research efforts have explored its potential applications in materials science, such as the synthesis of novel polymers or functional materials. Overall, 5-carboxy-2-thiouracil′s significance in scientific research lies in its versatility and potential for use as a valuable tool in organic synthesis, medicinal chemistry, and materials science, offering opportunities for the development of new compounds and materials with diverse applications.


5-Carboxy-2-thiouracil (CAS 23945-50-8) References

  1. Synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil.  |  Singh, UP., et al. 1998. Met Based Drugs. 5: 35-9. PMID: 18475822
  2. A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups.  |  Rice, AJ., et al. 2013. Anal Biochem. 441: 87-94. PMID: 23769705
  3. Specific conversion of s4 U to U in Escherichia coli tRNA by iodate oxidation.  |  Wong, KL. and Kearns, DR. 1975. Biochim Biophys Acta. 395: 381-7. PMID: 238620
  4. Eight new crystal structures of 5-(hydroxymethyl)uracil, 5-carboxyuracil and 5-carboxy-2-thiouracil: insights into the hydrogen-bonded networks and the predominant conformations of the C5-bound residues.  |  Seiler, VK., et al. 2016. Acta Crystallogr C Struct Chem. 72: 379-88. PMID: 27146565
  5. Different Oxidation Pathways of 2-Selenouracil and 2-Thiouracil, Natural Components of Transfer RNA.  |  Kulik, K., et al. 2020. Int J Mol Sci. 21: PMID: 32825053
  6. Structural requirements of thiol compounds in the inhibition of human liver iodothyronine 5'-deiodinase.  |  Harbottle, R. and Richardson, SJ. 1984. Biochem J. 217: 485-91. PMID: 6696743
  7. New latex-bonded pellicular anion exchangers with multi-phase selectivity for high-performance chromatographic separations  |  Stillian, J. R., & Pohl, C. A. 1990. Journal of Chromatography A. 499: 249-266.
  8. Structures and chemical equilibria of some N-heterocycles containing amide linkages  |  Masoud, M. S., Abd El Zaher Mostafa, M., Ahmed, R. H., & Abd El Moneim, N. H. 2003. Molecules. 8(5): 430-438.
  9. Synthesis and anti‐HIV activity of new 2‐thiolumazine and 2‐thiouracil metal complexes  |  Al‐Masoudi, N. A., Saleh, B. A., Karim, N. A., Issa, A. Y., & Pannecouque, C. 2011. Heteroatom Chemistry. 22(1): 44-50.
  10. Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review  |  Marinova, P. E., & Tamahkyarova, K. D. 2024. Compounds. 4(1): 186-213.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Carboxy-2-thiouracil, 5 g

sc-290833
5 g
$105.00